Pharmacology 2: Final Exam
Study online at https://quizlet.com/_gabft5
1. What is factor X and how is it - protein essential for clotting and coagula-
activated? tion
https://www.youtube.com/watch?v=cy3a__OOa2M
-
2. How does factor X play a role in
the clotting cascade and why is
it important?
3. What patient education needs - patients should have a diet consistent
to be given to patients taking in vitamin K ( leafy greens/ cheese/ oils/
warfarin regarding dietary in- herbs)
structions?
4. What is the reversal agent for vitamin k
warfarin?
5. What is the reversing agent for protamine sulfate
heparin?
6. Why do we use different rever- - vitamin K decreases the effectiveness of
sal agents for warfarin and he- warfarin
parin?
7. What are the risk factors for he- - OD / thrombocytopenia / bleeding
parin? ( check)
8. What are the contraindications - hypersensitivity to heparin
of heparin? - high risk for bleeding ( thrombocytopenia/
PUD/LP)
- use of other anticoagulants
9. What patient education should - injected subq into the abdomen in the 4
be given to those taking he- quadrants ( use belly button as midline)
parin regarding administration
and safety? - inject at a 90 degree angle
- change needle after drawing up/ air bub-
ble to lock med in
- do not massage or aspirate
, Pharmacology 2: Final Exam
Study online at https://quizlet.com/_gabft5
- IV heparin must have a double check /
make sure accurate weight in kg is in EMR
10. What is the most serious ad- - bleeding / hemorrhage
verse effect of anticoagulation - thrombocytopenia
therapy and why?
11. How might a patient on antico- - ICP/ GI bleed/ excessive bleeding
agulation therapy present?
12. How do we test for a therapeu- - INR should be 2-3 for most cases but
tic response of warfarin ? depends on the reason for treatment
- check daily for the first 5 days ( 2x weekly
for 1-2 weeks/ 1x weekly for 1-2 months
/every 2-4 weeks after)
13. How do we test for a therapeu- - PTT should be between 60-80 seconds
tic response to heparin? for therapeutic range ( check q4-6 at begin-
ning then daily)
14. What is the MOA of clopidogrel - blocks ADP receptors on platelets
( Plavix)?
- irreversible for life of platelet (7-10 days)
- P2Y12 Adenosine Diphosphate receptor
antagonist
15. What are the adverse effects of - nausea / dyspepsia/ abdominal pain
clopidogrel (Plavix)?
- bleeding/ severe neutropenia
- TTP ( thrombocytopenia/ hemolytic ane-
mia/ neurologic symptoms/ renal dysfunc-
tion/ fever) (rare but most common in 1st 2
weeks)
16. - administer routinely / take with food
Study online at https://quizlet.com/_gabft5
1. What is factor X and how is it - protein essential for clotting and coagula-
activated? tion
https://www.youtube.com/watch?v=cy3a__OOa2M
-
2. How does factor X play a role in
the clotting cascade and why is
it important?
3. What patient education needs - patients should have a diet consistent
to be given to patients taking in vitamin K ( leafy greens/ cheese/ oils/
warfarin regarding dietary in- herbs)
structions?
4. What is the reversal agent for vitamin k
warfarin?
5. What is the reversing agent for protamine sulfate
heparin?
6. Why do we use different rever- - vitamin K decreases the effectiveness of
sal agents for warfarin and he- warfarin
parin?
7. What are the risk factors for he- - OD / thrombocytopenia / bleeding
parin? ( check)
8. What are the contraindications - hypersensitivity to heparin
of heparin? - high risk for bleeding ( thrombocytopenia/
PUD/LP)
- use of other anticoagulants
9. What patient education should - injected subq into the abdomen in the 4
be given to those taking he- quadrants ( use belly button as midline)
parin regarding administration
and safety? - inject at a 90 degree angle
- change needle after drawing up/ air bub-
ble to lock med in
- do not massage or aspirate
, Pharmacology 2: Final Exam
Study online at https://quizlet.com/_gabft5
- IV heparin must have a double check /
make sure accurate weight in kg is in EMR
10. What is the most serious ad- - bleeding / hemorrhage
verse effect of anticoagulation - thrombocytopenia
therapy and why?
11. How might a patient on antico- - ICP/ GI bleed/ excessive bleeding
agulation therapy present?
12. How do we test for a therapeu- - INR should be 2-3 for most cases but
tic response of warfarin ? depends on the reason for treatment
- check daily for the first 5 days ( 2x weekly
for 1-2 weeks/ 1x weekly for 1-2 months
/every 2-4 weeks after)
13. How do we test for a therapeu- - PTT should be between 60-80 seconds
tic response to heparin? for therapeutic range ( check q4-6 at begin-
ning then daily)
14. What is the MOA of clopidogrel - blocks ADP receptors on platelets
( Plavix)?
- irreversible for life of platelet (7-10 days)
- P2Y12 Adenosine Diphosphate receptor
antagonist
15. What are the adverse effects of - nausea / dyspepsia/ abdominal pain
clopidogrel (Plavix)?
- bleeding/ severe neutropenia
- TTP ( thrombocytopenia/ hemolytic ane-
mia/ neurologic symptoms/ renal dysfunc-
tion/ fever) (rare but most common in 1st 2
weeks)
16. - administer routinely / take with food
