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"Systemic Lupus Erythematosus (SLE): Pathophysiology, Diagnosis, Treatment, and Nursing Care"

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This document provides an in-depth review of Systemic Lupus Erythematosus (SLE), focusing on its pathophysiology, clinical manifestations, diagnostic criteria, and treatment options. It explains the autoimmune nature of SLE, common symptoms such as the butterfly rash, joint pain, and lupus nephritis, and the diagnostic tests like ANA (Antinuclear Antibody) and other specific markers. The notes also cover pharmacologic management, including immunosuppressants, corticosteroids, and antimalarial drugs, as well as nursing interventions such as monitoring for complications, patient education on sun protection, and promoting self-care strategies. This resource is designed for nursing students to understand and manage patients with SLE effectively.

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Written in
2024/2025
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Systemic Lupus Erythematosus
(SLE; Lupus)


An autoimmune disease in which the immune system attac
own tissues, causing widespread inflammation and tissue dama
the affected organs.
* joints, skin, brain, lungs, kidneys, heart, and blood vessels.

CAUSES:*the main cause is still unknown.
Common in women especially African, Latina, & Asian
Hormone – Estrogen which increases during the reproductive
enhances the activity of B cells, autoantibodies in lupus.
Also affects T cells, promotes a pro-inflammatory immune re

, Systemic Lupus Erythematosus
(SLE; Lupus)



 Genetics – have harder to clear apoptotic bodies and control
inflammation

 Environmental factors – triggers like UV light, infections,
smoking, medications, and stress.
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Applicable for Filipino Nursing Student

This resource is specifically designed for Filipino nursing students. However, if the topics align with your curriculum, you may also find it useful. It contains a summarized module and practice questions covering Medical-Surgical Nursing (MS), Nursing Leadership and Management, and Nursing Research.

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