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Summary - Introduction To Biomedical Sciences (AB_1136)

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December 17, 2024
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‭2nd September‬
‭The Empirical Cycle (no need to know details, just overall picture):‬
‭-‬ ‭Empirical research = research based on observation and the measurement of‬
‭phenomena as directly experienced by the researcher‬
‭-‬ ‭Empirical evidence = objective evidence that appears the same, regardless of the‬
‭observer‬
‭-‬ ‭The empirical cycle (overview) = identifying the problem -> reviewing literature -> setting‬
‭research question, objective and hypothesis -> chose study design -> decide sample‬
‭design -> collecting data -> processing and analysing data -> writing report and evaluate‬
‭study -> identifying the problem (cycle repeats)‬
‭-‬ ‭Zoom in:‬
‭1.‬ ‭Identifying the problem: noticing a pattern/unexpected event/previous research‬
‭2.‬ ‭reviewing literature: what doe sthe research in this field already tell us about the‬
‭problem? Are there any gaps in the literature?‬
‭3.‬ ‭Research question and hypothesis: what exactly do you want to find out? Based‬
‭on observations, and literature, what do you think will happen?‬
‭4.‬ ‭Chose study design: how research variables will be measured (i.e. tools, unit of‬
‭measurement, degree of error), ethical consideration etc‬
‭5.‬ ‭Choose sample: how will you choose your sample of persons or events?‬
‭6.‬ ‭Collecting data: data collection following the study design‬
‭7.‬ ‭Processing and analysing data: what statistical methods need to be applied to‬
‭the data in order to accept/reject hypothesis?‬
‭8.‬ ‭Writing report and evaluate study: interpret results in terms of the hypothesis, if‬
‭prediction is confirmed; the hypothesis is supported (by the data), NOT proven!!‬

‭-‬ ‭ xample: the cause of Malaria‬
E
‭Death due to malaria is frequent -> research i.e germ theory -> setting ROS; what is the‬
‭cause of malaria? -> case/control study design (people w malaria vs people wo malaria)‬
‭-> blood samples collected -> data analysed (malaria blood had “moving granules”) ->‬
‭papers published (protosoan parasite causes malaria) -> where does the parasite come‬
‭from? (cycle continues)‬

‭-‬ ‭ hallenges along the way: getting research approved, money availability, data collection,‬
C
‭drawing the correct conclusion‬




‭9 September‬
‭Reading academic literature‬
‭1.‬ ‭What is scientific literature‬

, ‭ ow it is produced: researchers write about their research; these are the authors. This is then‬
H
‭submitted to a scientific/scholar journal (scientific journal =use peer review and do checks by‬
‭colleagues in the field). After the peer review, certain part may need to be‬
‭reconsidered/changed etc. Then finally, it is published. The process takes more than a year‬
‭Two types of scientific literature:‬
‭-‬ ‭Primary literature = original research article with surveys and case reports/case studies‬
‭-‬ ‭Secondary literature = review (can be narrative, systematic or meta-analysis (= specific‬
‭statistical analysis that is a combination of previous statistical studies), and you make a‬
‭summary of what is already known in the field‬

‭ .‬ ‭How can you look for it?‬
2
‭How to read it? You don't have to read all articles from start to finish, also some articles may‬
‭need to be re-read, it can be too complicated as well.‬

‭ .‬ ‭Steps‬
3
‭The method:‬
‭-‬ ‭Zapping: pick a relevant article (look for keywords, the type of literature, the journal and‬
‭the publication date (try to have the publication date at a max of 10 yrs ago)‬
‭-‬ ‭Skim reading: grasp the paper’s content, but not in details‬
‭-‬ ‭Structurally focused reading: understand the paper in depth‬




‭16th September‬
‭Variables and Descriptive statistics‬
‭What is methodology and statistics?‬
‭-‬ ‭Science is the process of collecting data through observations‬
‭-‬ ‭Methodology is the study of methods used to collect data, make observations, and‬
‭address RQ‬
‭-‬ ‭Statistics is a set of mathematical tools that help us draw conclusions‬
‭-‬ ‭If we want to observe something in a population for e.g., we will take a sample to use the‬
‭statics to describe our sample, and make inferences to answer our RQ‬
‭Types of variables?‬
‭-‬ ‭A variable is a characteristic of an individual. Can be categorized into two: a)their role in‬
‭a study, and b) the type of data they describe‬
‭a)‬ ‭Their role in a study: The independent variable ( is intentionally manipulated by‬
‭the researcher ) and the dependent variable (this is measured to determine our‬
‭experimental outcome) and the control variable (this variable is kept consistent‬
‭across all individuals)‬
‭b)‬ ‭The type of data they describe: we can classify data based on: categorical data‬
‭(=described with words) and quantitative data (=data in the form of numbers,‬
‭discrete)‬
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