PPI long term consequences - Answers osteoporosis, B 12 and iron deficiency
How would you treat peptic ulcer disease and H-pylori (H-pylori being the leading cause of peptic ulcer
with NSAIDS and aspirin being second leading causes) - Answers Triple therapy:
PPI twice a day
Amoxicillin 1gm BID or metronidazole
Clarithromycin 500mg daily for 7-14 days (10 days to 2 weeks recommended)
Then continue with PPI for 8-12 weeks
Step down with GERD - Answers Standard dose PPI x 8 weeks. If not resolved, double PPI dose for 4-8
weeks. After 4 weeks a lower dose of PPI is tried, if no relief after 8 weeks daily PPI then refer to GI. Step
down to lowest PPI dose or transition to H2RA blocker if symptoms are not relieved.
If first line GERD therapy fails (triple therapy), what is second line therapy? - Answers quadruple therapy.
PPI bid, metronidazole, tetracycline, bismuth subsalicylate x 14 days
Step up therapy for GERD? - Answers Lifestyle changes
antacids
H2RA
PPI
If GERD patient is already on a PPI, what is the next step? - Answers If the pt is already on a once daily
PPI, you increase to BID. If no improvement, referral to GI for endoscopy.
What would you recommend for travelers diarrhea? - Answers bismuth salisalate
After a patient is treated for H. Pylori, what is next? - Answers Take PPI for 8-12 weeks
What are monitoring parameters for chronic long term proton pump therapy? - Answers Anemia,
osteoporosis, iron, B12, calcium, magnesium
How does metoclopramide improve GERD symptoms? - Answers It increases lower esophageal tone due
to it's antagonist activity at the D2 receptors and the chemoreceptor trigger zone in the CNS.
If you have a GERD patient and they are taking TUMS (calcium carbonate) but their symptoms are
minimally relieved, what is the next step for therapy? - Answers H2RA & PPI
What is the action of loperamide (immodium) when treating diarrhea? - Answers Loperamide acts on
the opioid receptors in the myenteric plexus in the large intestine, decreasing the activity and