Microbiology Chapter 14 (OpenStax)
A scientist discovers that a soil bacterium she has been studying produces an antimicrobial that kills
gram-negative bacteria. She isolates and purifies the antimicrobial compound, then chemically converts
a chemical side chain to a hydroxyl group. When she tests the antimicrobial properties of the new
version, she finds that this antimicrobial drug can now also kill gram-positive bacteria. The new
antimicrobial drug with broad-spectrum activity is considered to be which of the following? - correct
answer semisynthetic
Which of the following antimicrobial drugs is synthetic? - correct answer Sulfanilamide
Which of the following combinations would most likely contribute to the development of a
superinfection? - correct answer Long term use of a broad-spectrum antimicrobial
Which of the following routes of administration would be appropriate and convenient for home and
administration of an antimicrobial to treat a systemic infection? - correct answer oral
Which clinical situation would be appropriate for treatment with a narrow-spectrum antimicrobial drug?
- correct answer treatment of strep throat caused by culture identified Streptococcus pygenes
Which of the following terms refers to the ability of an antimicrobial drug to harm the target microbe
without harming the host? - correct answer selective toxicity
Which of the following is not a type of beta-lactam antimicrobial? - correct answer gylcopeptides
Which of the following does not bind to the 50S ribosomal subunit? - correct answer tetracyclines
Which of the following antimicrobials inhibits the activity of DNA gyrase? - correct answer nalidixic acid
Which of the following is not an appropriate target for antifungal drugs? - correct answer cholesterol
Which of the following drug classes specifically inhibits neuronal transmission in helminths? - correct
answer avermectins
A scientist discovers that a soil bacterium she has been studying produces an antimicrobial that kills
gram-negative bacteria. She isolates and purifies the antimicrobial compound, then chemically converts
a chemical side chain to a hydroxyl group. When she tests the antimicrobial properties of the new
version, she finds that this antimicrobial drug can now also kill gram-positive bacteria. The new
antimicrobial drug with broad-spectrum activity is considered to be which of the following? - correct
answer semisynthetic
Which of the following antimicrobial drugs is synthetic? - correct answer Sulfanilamide
Which of the following combinations would most likely contribute to the development of a
superinfection? - correct answer Long term use of a broad-spectrum antimicrobial
Which of the following routes of administration would be appropriate and convenient for home and
administration of an antimicrobial to treat a systemic infection? - correct answer oral
Which clinical situation would be appropriate for treatment with a narrow-spectrum antimicrobial drug?
- correct answer treatment of strep throat caused by culture identified Streptococcus pygenes
Which of the following terms refers to the ability of an antimicrobial drug to harm the target microbe
without harming the host? - correct answer selective toxicity
Which of the following is not a type of beta-lactam antimicrobial? - correct answer gylcopeptides
Which of the following does not bind to the 50S ribosomal subunit? - correct answer tetracyclines
Which of the following antimicrobials inhibits the activity of DNA gyrase? - correct answer nalidixic acid
Which of the following is not an appropriate target for antifungal drugs? - correct answer cholesterol
Which of the following drug classes specifically inhibits neuronal transmission in helminths? - correct
answer avermectins
