BOC HEMATOLOGY 6TH EDITION
The following are compounds formed in the synthesis of heme:
1 coproporphyrinogen
2 porphobilinogen
3 uroporphyrinogen
3 protoporphyrinogen
Which of the following responses lists these compounds in the order in which they are formed?
a. 4, 3, 1, 2,
b. 2, 3, 1, 4
c. 4, 2, 3, 1
d. 2, 1, 3, 4 - (ANSWER)b
The majority of the iron in an adult is found as a constituent of:
a. hemoglobin
b. hemosiderin
c. myoglobin
d. transferrin - (ANSWER)a
In order for hemoglobin to combine reversibly with oxygen, the iron must be:
a complexed with haptoglobin
b. freely circulating in the cytoplasm
c. attached to transferrin
d. in the ferrous state - (ANSWER)d
Which description best fits the Donath-Landsteiner antibody?
a. IgM cold agglutinin
b. Biphasic IgM hemolysin
,c. IgG biphasic hemolysin
d. IgG warm agglutinin - (ANSWER)c
Which of the following ions is bound to hemoglobin in methemoglobin?
a. Ca2+
b. Fe3+
c. Fe3+
d. Mg2+ - (ANSWER)b
An increased amount of cytoplasmic basophilia in a blood cell indicates:
a. increased cytoplasmic maturation
b. decreased cytoplasmic maturation
c. reduction in size of the cell
d. decreased nuclear maturation - (ANSWER)b
Specific (secondary) granules of the neutrophilic granulocyte:
a. appear first at the myelocyte stage
b. contain esterases
c. are formed on the mitochondria
d. are derived from azurophil (primary) granules - (ANSWER)a
In normal adult bone marrow, the most common granulocyte is the?
a. basophil
b. myeloblast
c. eosinophil
d. metamyelocyte - (ANSWER)d
Pluripotent hematopoietic stem cells are capable of producing:
,a. daughter cells of only one cell line
b. only T lymphocytes and B lymphocytes
c. erytropoietin, thrombopoietin, and leukopoietin
d. lymphoid and myeloid stem cells - (ANSWER)d
Which of the following cytokines is most responsible for eosinophil differentiation and release
from the bone marrow?
a. IL-1
b. IL-2
c. IL-4
d. IL-5 - (ANSWER)d
Auer rods are characterized as:
a. fused primary granules
b. DNA precipitates
c. denatured hemoglobin
d. large cytoplasmic granules - (ANSWER)b
Which of the following is characteristic of cellular changes as megakaryoblasts mature into
megakaryocytes with the bone marrow?
a. progressive decrease in overall cell size
b. increasing basophilia of cytoplasm
c. nuclear division without cytoplasmic division
d. fusion of the nuclear lobes - (ANSWER)c
Which of the following cells is the largest cell in the bone marrow:
a. megakaryocyte
b. histiocyte
c. osteoblast
, d. mast cell - (ANSWER)a
Which one of the following is a true statement about megakaryocytes in a bone marrow aspirate?
a. an average of 2-10 should be found in each low power field (10x)
b. the majority of forms are the MK1 stage
c. morphology must be determined from the biopsy section
d. quantitative estimation is done using the 100x oil immersion lens - (ANSWER)a
After the removal of red blood cells from the circulation, hemoglobin is broken down into:
a. iron, porphyrin, and amino acids
b. iron, protoporphyrin, and globin
c. heme, protoporphyrin, and amino acids
d. heme, hemosiderin, and globin - (ANSWER)b
The main function of the hexose monophosphate shunt in the erythrocyte is to:
a. regulate the level of 2,3-DPG
b. provide reduced glutatione to prevent hemoglobin oxidation
c. prevent the reduction of heme to iron
d. provide energy for membrane maintenance - (ANSWER)b
In the normal adult, the spleen acts as a site for:
A. storage of RBCs
B. production of RBCs
C. synthesis of erythropoietin
D. removal of imperfect and aging cells - (ANSWER)d
Cells for the transport of O2 and CO2 are:
The following are compounds formed in the synthesis of heme:
1 coproporphyrinogen
2 porphobilinogen
3 uroporphyrinogen
3 protoporphyrinogen
Which of the following responses lists these compounds in the order in which they are formed?
a. 4, 3, 1, 2,
b. 2, 3, 1, 4
c. 4, 2, 3, 1
d. 2, 1, 3, 4 - (ANSWER)b
The majority of the iron in an adult is found as a constituent of:
a. hemoglobin
b. hemosiderin
c. myoglobin
d. transferrin - (ANSWER)a
In order for hemoglobin to combine reversibly with oxygen, the iron must be:
a complexed with haptoglobin
b. freely circulating in the cytoplasm
c. attached to transferrin
d. in the ferrous state - (ANSWER)d
Which description best fits the Donath-Landsteiner antibody?
a. IgM cold agglutinin
b. Biphasic IgM hemolysin
,c. IgG biphasic hemolysin
d. IgG warm agglutinin - (ANSWER)c
Which of the following ions is bound to hemoglobin in methemoglobin?
a. Ca2+
b. Fe3+
c. Fe3+
d. Mg2+ - (ANSWER)b
An increased amount of cytoplasmic basophilia in a blood cell indicates:
a. increased cytoplasmic maturation
b. decreased cytoplasmic maturation
c. reduction in size of the cell
d. decreased nuclear maturation - (ANSWER)b
Specific (secondary) granules of the neutrophilic granulocyte:
a. appear first at the myelocyte stage
b. contain esterases
c. are formed on the mitochondria
d. are derived from azurophil (primary) granules - (ANSWER)a
In normal adult bone marrow, the most common granulocyte is the?
a. basophil
b. myeloblast
c. eosinophil
d. metamyelocyte - (ANSWER)d
Pluripotent hematopoietic stem cells are capable of producing:
,a. daughter cells of only one cell line
b. only T lymphocytes and B lymphocytes
c. erytropoietin, thrombopoietin, and leukopoietin
d. lymphoid and myeloid stem cells - (ANSWER)d
Which of the following cytokines is most responsible for eosinophil differentiation and release
from the bone marrow?
a. IL-1
b. IL-2
c. IL-4
d. IL-5 - (ANSWER)d
Auer rods are characterized as:
a. fused primary granules
b. DNA precipitates
c. denatured hemoglobin
d. large cytoplasmic granules - (ANSWER)b
Which of the following is characteristic of cellular changes as megakaryoblasts mature into
megakaryocytes with the bone marrow?
a. progressive decrease in overall cell size
b. increasing basophilia of cytoplasm
c. nuclear division without cytoplasmic division
d. fusion of the nuclear lobes - (ANSWER)c
Which of the following cells is the largest cell in the bone marrow:
a. megakaryocyte
b. histiocyte
c. osteoblast
, d. mast cell - (ANSWER)a
Which one of the following is a true statement about megakaryocytes in a bone marrow aspirate?
a. an average of 2-10 should be found in each low power field (10x)
b. the majority of forms are the MK1 stage
c. morphology must be determined from the biopsy section
d. quantitative estimation is done using the 100x oil immersion lens - (ANSWER)a
After the removal of red blood cells from the circulation, hemoglobin is broken down into:
a. iron, porphyrin, and amino acids
b. iron, protoporphyrin, and globin
c. heme, protoporphyrin, and amino acids
d. heme, hemosiderin, and globin - (ANSWER)b
The main function of the hexose monophosphate shunt in the erythrocyte is to:
a. regulate the level of 2,3-DPG
b. provide reduced glutatione to prevent hemoglobin oxidation
c. prevent the reduction of heme to iron
d. provide energy for membrane maintenance - (ANSWER)b
In the normal adult, the spleen acts as a site for:
A. storage of RBCs
B. production of RBCs
C. synthesis of erythropoietin
D. removal of imperfect and aging cells - (ANSWER)d
Cells for the transport of O2 and CO2 are:
