COMSAE PRACTICE EXAM WITH CORRECT
ACTUAL QUESTIONS AND CORRECTLY
WELL DEFINED ANSWERS LATEST 2024 –
2025 ALREADY GRADED A+
Adaptive Immunity - ANSWERS--T cells, B cells, circulating antibodies
-variable mechanism thur VDJ recombination during lymph develop
-resistance= microbial resist not heritable
-pathogen response: high specific, refine over time, develop over long period;
memory response is faster and robust
-Secreted proteins: immunoglobulins
-Key feature: memory cell=active B and T cell subsequent expose to previous
encounter Ag>> stronger, quicker IR
Major Histocompatibility complexes - ANSWERS-MHC encode by HLA genes;
present Ag fragments to T cells and bind T cell receptors (TCRs)
MHC I - ANSWERS-HLA,B,C
I has one letter
bind: TCR and CD8
, structure: 1 long 1 short
Express: all nucleated cells, APCs, platelets (not on RBCs)
Fxn: present endogenous synth Ag's (viral or cytosolic proteins) to CD8+ cytotoxic
T cells
Ag loading: loaded MHC I in RER after deliver via TAP
Assoc: Beta 2 microglobulin
MHC II - ANSWERS-HLA-DP, HLA-DQ, HLA-DR
(II has 2 letters)
bind: TCR and CD4
structure: 2 equal length chain
express: APCs
Fxn: present exogenous synth ags (bacterial proteins) CD4 helper T cells
Ag loaded follow invariant chain in acidified endosome;
Assoc: invariant chain
HLA A3 - ANSWERS-hemochromatosis
B8 - ANSWERS-Addison, myasthenia graves, Graves dz
B27 - ANSWERS-psoriatic arthritis, ankylosing spondylitis, IBD assoc arthritis,
Reactive arthritis
ACTUAL QUESTIONS AND CORRECTLY
WELL DEFINED ANSWERS LATEST 2024 –
2025 ALREADY GRADED A+
Adaptive Immunity - ANSWERS--T cells, B cells, circulating antibodies
-variable mechanism thur VDJ recombination during lymph develop
-resistance= microbial resist not heritable
-pathogen response: high specific, refine over time, develop over long period;
memory response is faster and robust
-Secreted proteins: immunoglobulins
-Key feature: memory cell=active B and T cell subsequent expose to previous
encounter Ag>> stronger, quicker IR
Major Histocompatibility complexes - ANSWERS-MHC encode by HLA genes;
present Ag fragments to T cells and bind T cell receptors (TCRs)
MHC I - ANSWERS-HLA,B,C
I has one letter
bind: TCR and CD8
, structure: 1 long 1 short
Express: all nucleated cells, APCs, platelets (not on RBCs)
Fxn: present endogenous synth Ag's (viral or cytosolic proteins) to CD8+ cytotoxic
T cells
Ag loading: loaded MHC I in RER after deliver via TAP
Assoc: Beta 2 microglobulin
MHC II - ANSWERS-HLA-DP, HLA-DQ, HLA-DR
(II has 2 letters)
bind: TCR and CD4
structure: 2 equal length chain
express: APCs
Fxn: present exogenous synth ags (bacterial proteins) CD4 helper T cells
Ag loaded follow invariant chain in acidified endosome;
Assoc: invariant chain
HLA A3 - ANSWERS-hemochromatosis
B8 - ANSWERS-Addison, myasthenia graves, Graves dz
B27 - ANSWERS-psoriatic arthritis, ankylosing spondylitis, IBD assoc arthritis,
Reactive arthritis
