APHON Principles of Biotherapy
biotherapy - answer modality of tx: agents that resemble body's own defense and
surveillance systems. can augment/modulate/restore host's immune response, direct
antitumor activity, other biological effects. side effects typically hypersensitivity rx
immune surveillance - answer tumor cells express abnormal tumor antigens on surface
that can be recognized/destroyed by immune system
natural killer cells - answer lymphocyte that recognizes/kills malignant cells
cytotoxic t cells - answer recognize tumor-associated antigens and kills cells
interferons - answer multiple moa's & produced w/ recombinant dna.
protein capable of protecting other cells from viral infections by interfering w/ viral
replication.
family of glycoproteins include: antiviral, antiproliferative, potent immunomodulatory
effects
cytokines - answer products of immune cells to enhance cytotoxic activity of cells and
increase immune response
alpha-interferon - answer leukocyte-derived. tx: hairy cell leukemia, melanoma, chronic
myeloid leukemia, follicular lymphoma, multiple myeloma, cutaneous t-cell lymphoma
beta-interferon - answer fibroblast-derived. tx MS
gamma-interferon - answert-lymphocyte derived. tx chronic granulomatous disease
interleukin-2 - answerproduced by t-helper cells & stimulate growth/maturation of t-cell
subsets, cytotoxic t-cells, production of lymphokines & cytokines.
act as chemical signals b/w wbc's (revs up immune system)
retinoids - answerimmunomodulators that facilitate differentiation & suppress
proliferation of cancer cells
all-trans retinoic acid (atra) - answertx: aml, aml m3 subtype, apl
increase maturation of promyelocytic blasts and rapid resolution of coagulopathy r/t tx.
isotretinoin (accutane) - answerretinoid tx neuroblastoma.
have antitumor activity unknown moa. TERATOGENIC. male/female pt must register
iPledge (fetal exposure). can also affect hearing & vision
biotherapy - answer modality of tx: agents that resemble body's own defense and
surveillance systems. can augment/modulate/restore host's immune response, direct
antitumor activity, other biological effects. side effects typically hypersensitivity rx
immune surveillance - answer tumor cells express abnormal tumor antigens on surface
that can be recognized/destroyed by immune system
natural killer cells - answer lymphocyte that recognizes/kills malignant cells
cytotoxic t cells - answer recognize tumor-associated antigens and kills cells
interferons - answer multiple moa's & produced w/ recombinant dna.
protein capable of protecting other cells from viral infections by interfering w/ viral
replication.
family of glycoproteins include: antiviral, antiproliferative, potent immunomodulatory
effects
cytokines - answer products of immune cells to enhance cytotoxic activity of cells and
increase immune response
alpha-interferon - answer leukocyte-derived. tx: hairy cell leukemia, melanoma, chronic
myeloid leukemia, follicular lymphoma, multiple myeloma, cutaneous t-cell lymphoma
beta-interferon - answer fibroblast-derived. tx MS
gamma-interferon - answert-lymphocyte derived. tx chronic granulomatous disease
interleukin-2 - answerproduced by t-helper cells & stimulate growth/maturation of t-cell
subsets, cytotoxic t-cells, production of lymphokines & cytokines.
act as chemical signals b/w wbc's (revs up immune system)
retinoids - answerimmunomodulators that facilitate differentiation & suppress
proliferation of cancer cells
all-trans retinoic acid (atra) - answertx: aml, aml m3 subtype, apl
increase maturation of promyelocytic blasts and rapid resolution of coagulopathy r/t tx.
isotretinoin (accutane) - answerretinoid tx neuroblastoma.
have antitumor activity unknown moa. TERATOGENIC. male/female pt must register
iPledge (fetal exposure). can also affect hearing & vision
