COMSAE Drugs Exam Questions and
Answers
Warfarin- Mechanism - Answers -Interferes w/ vitamin K dependent clotting factors (II,
VII, IX, X, C, S)
Warfarin- Pathway, effect on PT/INR - Answers -Extrinsic factor, increased PT
Warfarin- Clinical Use - Answers -Chronic anticoagulation
Warfarin- Pregnancy - Answers -CI in pregnant women--crosses placenta
Warfarin- AE - Answers -Bleeding, tissue necrosis
Digoxin- MOA - Answers -Direct inhibition of Na/K ATPase --> indirect inhibition of
Na/Ca exchange
Increased Calcium concentration --> positive ionotropy.
Stimulates vagus nerve --> decrease HR
Digoxin- Clinical use - Answers -Heart failure (increase contractility)
atrial fibrillation (decrease conduction at AV node and depression of SA node)
Digoxin- AE - Answers -Hyperkalemia, blurry yellow vision, arrhythmias, AV block
Digoxin Toxicity- Treatment - Answers -Slowly normalize K+, cardiac pacer, anti-digoxin
Fab fragments, Mg+
Beta Blockers- Mechanism - Answers -Decrease SA and AV nodal activity by
decreasing cAMP/Ca2+
Decrease slope of phase 4
Beta Blockers- Use - Answers -SVT, ventricular rate control for a-fib and a-flutter
Beta Blockers- AE - Answers -Exacerbation of COPD/asthma
CV effects: bradycardia, AV block, HF
Metronidazole- MOA - Answers -Forms toxic free radical metabolites in bacteria.
Bacteriocidal
Metronidazole- Clinical Use - Answers -GET GAP
Answers
Warfarin- Mechanism - Answers -Interferes w/ vitamin K dependent clotting factors (II,
VII, IX, X, C, S)
Warfarin- Pathway, effect on PT/INR - Answers -Extrinsic factor, increased PT
Warfarin- Clinical Use - Answers -Chronic anticoagulation
Warfarin- Pregnancy - Answers -CI in pregnant women--crosses placenta
Warfarin- AE - Answers -Bleeding, tissue necrosis
Digoxin- MOA - Answers -Direct inhibition of Na/K ATPase --> indirect inhibition of
Na/Ca exchange
Increased Calcium concentration --> positive ionotropy.
Stimulates vagus nerve --> decrease HR
Digoxin- Clinical use - Answers -Heart failure (increase contractility)
atrial fibrillation (decrease conduction at AV node and depression of SA node)
Digoxin- AE - Answers -Hyperkalemia, blurry yellow vision, arrhythmias, AV block
Digoxin Toxicity- Treatment - Answers -Slowly normalize K+, cardiac pacer, anti-digoxin
Fab fragments, Mg+
Beta Blockers- Mechanism - Answers -Decrease SA and AV nodal activity by
decreasing cAMP/Ca2+
Decrease slope of phase 4
Beta Blockers- Use - Answers -SVT, ventricular rate control for a-fib and a-flutter
Beta Blockers- AE - Answers -Exacerbation of COPD/asthma
CV effects: bradycardia, AV block, HF
Metronidazole- MOA - Answers -Forms toxic free radical metabolites in bacteria.
Bacteriocidal
Metronidazole- Clinical Use - Answers -GET GAP
