APHON PRINCIPLES OF CHEMO AND
BIOTHERAPY EXAM QUESTIONS AND
VERIFIED ANSWERS
Biotherapy: AN ANSWER Another name for targeted anticancer drugs is
biological response modifiers (BRM).
Which class of drugs are known as tyrosine kinase inhibitors (TKIs)? ANSWER
Biotherapy
What class are monoclonal antibodies (MoAbs)? - ANSWER Biotherapy
ANSWER: Pharmacokinetics is the study of drug metabolism, excretion, and
absorption.
ANSWER: Describe pharmacodynamics. The drug's level in the bloodstream
and the way it causes a reaction
ANSWER: Describe adjuvant chemotherapy. chemotherapy is used to treat
undetected metastases or leftover disease following another form of therapy,
including surgery.
ANSWER: Describe neoadjuvant chemotherapy. when chemotherapy is
administered before surgery to reduce the tumour burden and facilitate surgical
tumour removal.
Describe sanctuary locations. ANSWER Locations in the body where tumor
cells hide and are difficult for chemotherapy to reach, including the central
nervous system
ANSWER: Which normal cells are most frequently affected by chemotherapy?
Hair follicles, mucosal (mouth and GI), and hematopoietic
ANSWER: Why Use Chemotherapy? to stop cancer cells from proliferating,
spreading, and eventually killing the patient
, Cure: ANSWER To remove the cancer forever
Control: ANSWER When a cure is neither practical or practicable, to prolong
the duration and quality of life
Palliation: Response Reduce sorrow and agony at the end of life
Cell cycle resting phase: ANSWER Cells not dividing (gap 0)
Postmitotic phase-ANSWER Gap 1: RNA and protein synthesis occurs, and
enzymes required for DNA synthesis are generated (18 hours)
Phase of Synthesis (S): ANSWER Cellular DNA replication (20 hours)
Phase premitotic: ANSWER Gap 2: RNA and protein synthesis take place, and
mitotic spindle precursors are created. The shortest stage
Phase of Mitosis (M): ANSWER Prophase, Metaphase, Anaphase, and
Telophase are the four stages of cell division that last for one hour.
Five phases of cell reproduction - ANSWER Postmitotic, synthesis, premitotic,
mitotic, and resting
Time of cell cycle: ANSWER how long it takes a cell to transition between
mitotic episodes.
Agents specific to the cell cycle ANSWER: medications that only function
when cells are in a particular stage of the cell cycle.
ANSWER: Doubling time The amount of time needed for a tumor mass to
double in size or reach a specific size.
Growth percentage: ANSWER proportion of cells that are actively dividing at
any given moment.
ANSWER for tumor burden The amount of cells in the tumor determines its
size.
BIOTHERAPY EXAM QUESTIONS AND
VERIFIED ANSWERS
Biotherapy: AN ANSWER Another name for targeted anticancer drugs is
biological response modifiers (BRM).
Which class of drugs are known as tyrosine kinase inhibitors (TKIs)? ANSWER
Biotherapy
What class are monoclonal antibodies (MoAbs)? - ANSWER Biotherapy
ANSWER: Pharmacokinetics is the study of drug metabolism, excretion, and
absorption.
ANSWER: Describe pharmacodynamics. The drug's level in the bloodstream
and the way it causes a reaction
ANSWER: Describe adjuvant chemotherapy. chemotherapy is used to treat
undetected metastases or leftover disease following another form of therapy,
including surgery.
ANSWER: Describe neoadjuvant chemotherapy. when chemotherapy is
administered before surgery to reduce the tumour burden and facilitate surgical
tumour removal.
Describe sanctuary locations. ANSWER Locations in the body where tumor
cells hide and are difficult for chemotherapy to reach, including the central
nervous system
ANSWER: Which normal cells are most frequently affected by chemotherapy?
Hair follicles, mucosal (mouth and GI), and hematopoietic
ANSWER: Why Use Chemotherapy? to stop cancer cells from proliferating,
spreading, and eventually killing the patient
, Cure: ANSWER To remove the cancer forever
Control: ANSWER When a cure is neither practical or practicable, to prolong
the duration and quality of life
Palliation: Response Reduce sorrow and agony at the end of life
Cell cycle resting phase: ANSWER Cells not dividing (gap 0)
Postmitotic phase-ANSWER Gap 1: RNA and protein synthesis occurs, and
enzymes required for DNA synthesis are generated (18 hours)
Phase of Synthesis (S): ANSWER Cellular DNA replication (20 hours)
Phase premitotic: ANSWER Gap 2: RNA and protein synthesis take place, and
mitotic spindle precursors are created. The shortest stage
Phase of Mitosis (M): ANSWER Prophase, Metaphase, Anaphase, and
Telophase are the four stages of cell division that last for one hour.
Five phases of cell reproduction - ANSWER Postmitotic, synthesis, premitotic,
mitotic, and resting
Time of cell cycle: ANSWER how long it takes a cell to transition between
mitotic episodes.
Agents specific to the cell cycle ANSWER: medications that only function
when cells are in a particular stage of the cell cycle.
ANSWER: Doubling time The amount of time needed for a tumor mass to
double in size or reach a specific size.
Growth percentage: ANSWER proportion of cells that are actively dividing at
any given moment.
ANSWER for tumor burden The amount of cells in the tumor determines its
size.
