PATHOPHYSIOLOGY
THE BIOLOGIC BASIS FOR DISEASE IN ADULTS AND CHILDREN
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8th Edition
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Kathryn L. McCance, Sue E. Huether
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,Contents
Chaptergs01:gsCellulargsBiology ........................................................................................................................ 4
Chaptergs02:gsAlteredgsCellulargsandgsTissuegsBiology:gsEnvironmentalgsAgents .............................................. 18
Chaptergs03:gsThegsCellulargsEnvironment:gsFluidsgsandgsElectrolytes,gsAcidsgsandgsBases................................ 31
Chaptergs04:gsGenesgsandgsGeneticgsDiseases ................................................................................................ 44
Chaptergs05:gsGenes,gsEnvironment-Lifestyle,gsandgsCommongsDiseases ....................................................... 55
Chaptergs06:gsEpigeneticsgsandgsDisease ....................................................................................................... 63
Chaptergs07:gsInnategsImmunity:gsInflammationgsandgsWoundgsHealing......................................................... 68
Chaptergs08:gsAdaptivegsImmunity ................................................................................................................ 83
Chaptergs09:gsAlterationsgsingsImmunitygsandgsInflammation ......................................................................... 95
Chaptergs10:gsInfection ............................................................................................................................... 108
Chaptergs11:gsStressgsandgsDisease .............................................................................................................. 117
Chaptergs12:gsCancergsBiology ..................................................................................................................... 124
Chaptergs13:gsCancergsEpidemiology ........................................................................................................... 137
Chaptergs14:gsCancergsingsChildren............................................................................................................... 143
Chaptergs15:gsStructuregsandgsFunctiongsofgsthegsNeurologicgsSystem ........................................................... 148
Chaptergs16:gsPain,gsTemperaturegsRegulation,gsSleep,gsandgsSensorygsFunction .......................................... 159
Chaptergs17:gsAlterationsgsingsCognitivegsSystems,gsCerebralgsHemodynamics,gsandgsMotorgsFunction ......... 174
Chaptergs18:gsDisordersgsofgsthegsCentralgsandgsPeripheralgsNervousgsSystemsgsandgsthegsNeuromusculargsJunctio
n
..................................................................................................................................................................gs188
Chaptergs19:gsNeurobiologygsofgsSchizophrenia,gsMoodgsDisorders,gsandgsAnxietygsDisorders ...................... 199
Chaptergs20:gsAlterationsgsofgsNeurologicgsFunctiongsingsChildren................................................................. 206
Chaptergs21:gsMechanismsgsofgsHormonalgsRegulation ................................................................................ 213
Chaptergs22:gsAlterationsgsofgsHormonalgsRegulation .................................................................................. 222
Chaptergs23:gsObesitygsandgsDisordersgsofgsNutrition ................................................................................... 234
Chaptergs24:gsStructuregsandgsFunctiongsofgsthegsReproductivegsSystems ..................................................... 239
Chaptergs25:gsAlterationsgsofgsthegsFemalegsReproductivegsSystem .............................................................. 249
Chaptergs26:gsAlterationsgsofgsthegsMalegsReproductivegsSystem.................................................................. 259
Chaptergs27:gsSexuallygsTransmittedgsInfections ......................................................................................... 265
Chaptergs28:gsStructuregsandgsFunctiongsofgsthegsHematologicgsSystem ........................................................ 273
,Chaptergs29:gsAlterationsgsofgsErythrocytes,gsPlatelets,gsandgsHemostaticgsFunction .................................... 283
Chaptergs30:gsAlterationsgsofgsLeukocytegsandgsLymphoidgsFunction ............................................................ 293
Chaptergs31:gsAlterationsgsofgsHematologicgsFunctiongsingsChildren ............................................................. 300
Chaptergs32:gsStructuregsandgsFunctiongsofgsthegsCardiovasculargsandgsLymphaticgsSystems ......................... 311
Chaptergs33:gsAlterationsgsofgsCardiovasculargsFunction .............................................................................. 324
Chaptergs34:gsAlterationsgsofgsCardiovasculargsFunctiongsingsChildren .......................................................... 338
Chaptergs35:gsStructuregsandgsFunctiongsofgsthegsPulmonarygsSystem ........................................................... 346
Chaptergs36:gsAlterationsgsofgsPulmonarygsFunction .................................................................................... 356
Chaptergs37:gsAlterationsgsofgsPulmonarygsFunctiongsingsChildren................................................................. 373
Chaptergs38:gsStructuregsandgsFunctiongsofgsthegsRenalgsandgsUrologicgsSystems ........................................... 381
Chaptergs39:gsAlterationsgsofgsRenalgsandgsUrinarygsTractgsFunction.............................................................. 391
Chaptergs40:gsAlterationsgsofgsRenalgsandgsUrinarygsTractgsFunctiongsingsChildren .......................................... 401
Chaptergs41:gsStructuregsandgsFunctiongsofgsthegsDigestivegsSystem .............................................................. 409
Chaptergs42:gsAlterationsgsofgsDigestivegsFunction ....................................................................................... 421
Chaptergs43:gsAlterationsgsofgsDigestivegsFunctiongsingsChildren ................................................................... 432
Chaptergs44:gsStructuregsandgsFunctiongsofgsthegsMusculoskeletalgsSystem .................................................. 441
Chaptergs45:gsAlterationsgsofgsMusculoskeletalgsFunction ........................................................................... 453
Chaptergs46:gsAlterationsgsofgsMusculoskeletalgsFunctiongsingsChildren ........................................................ 466
Chaptergs47:gsStructure,gsFunction,gsandgsDisordersgsofgsthegsIntegument .................................................... 475
Chaptergs48:gsAlterationsgsofgsthegsIntegumentgsingsChildren........................................................................ 486
Chaptergs49:gsShock,gsMultiplegsOrgangsDysfunctiongsSyndrome,gsandgsBurnsgsingsAdults.............................. 494
Chaptergs50:gsShock,gsMultiplegsOrgangsDysfunctiongsSyndrome,gsandgsBurnsgsingsChildren .......................... 502
, TestgsBankgs-gsPathophysiology:gsThegsBiologicgsBasisgsforgsDiseasegsingsAdultsgsandgsChildrengs(8th)gsgsgsgsg s 4
Chapter 01: Cellular Biology
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MULTIPLEgsCHOICE
1. Whichgsstatementgsbestgsdescribesgsthegscellulargsfunctiongsofgsmetabolicgsabsorption?
a. Cellsgscangsproducegsproteins.
b. Cellsgscangssecretegsdigestivegsenzymes.
c. Cellsgscangstakegsingsandgsusegsnutrients.
d. Cellsgscangssynthesizegsfats.
ANS:g s C
Ingsmetabolicgsabsorption,gsallgscellsgstakegsingsandgsusegsnutrientsgsandgsothergssubstancesgsfromgstheirgss
urroundings.gsThegsremaininggsoptionsgsaregsnotgsinclusivegsingstheirgsdescriptionsgsofgscellulargsmetabo
licgsabsorption.
PTS:gsgsg s 1 DIF: CognitivegsLevel:gsRemembering
2. Wheregsisgsmostgsofgsagscell’sgsgeneticgsinformation,gsincludinggsRNAgsandgsDNA,gscontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS:g s C
Thegsnucleusgscontainsgsthegsnucleolus,gsagssmallgsdensegsstructuregscomposedgslargelygsofgsRNA,gsmo
stgsofgsthegscellulargsDNA,gsandgsthegsDNA-
bindinggsproteins,gssuchgsasgsthegshistones,gswhichgsregulategsitsgsactivity.gsThegsmitochondriagsaregsres
ponsiblegsforgscellulargsrespirationgsandgsenergygsproduction.
Ribosomes’gschiefgsfunctiongsisgstogsprovidegssitesgsforgscellulargsproteingssynthesis.gsLysosomesgsfunc
tiongsasgsthegsintracellulargsdigestivegssystem.
PTS:gsgsg s 1 DIF: CognitivegsLevel:gsRemembering
3. Whichgscomponentgsofgsthegscellgsproducesgshydrogengsperoxidegs(H2O2)gsbygsusinggsoxygengstogsrem
ovegshydrogengsatomsgsfromgsspecificgssubstratesgsingsangsoxidativegsreaction?
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS:g s B