PHAR 100 Assessment Tools Exam
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The ultra short duration of action of thiopental is due to:
a. Rapid breakdown in the liver
b. Rapid excretion by the lungs
c. Redistribution of the drug from the brain to muscle and fat
d. Rapid excretion by the kidney
e. Poor penetration into the brain - ✔✔c. Redistribution of the drug from the
brain to muscle and fat
Which of the following statements is correct?
a. The generic name of a drug is a non-proprietary name
b. If a drug is marketed by more than one company, it may have several
brand (proprietary) names
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c. Drug products made by different drug companies usually yield similar
blood levels as they are approved for market on the basis of producing
similar blood levels to the name brand product
d. For orally administered drugs, acting outside the gastrointestinal tract, it
is only that portion of the drug that goes into solution in the fluids of the
stomach and intestine that can be absorbed into the blood and exert an
effect
e. All of the above - ✔✔e. All of the above
Drug A can only relieve pain of mild intensity. Drug B, on the other hand,
relieves pain of very marked intensity. From this information, one can
conclude that:
a. Drug A has greater efficacy than Drug B
b. Drug B has greater efficacy than Drug A
c. Drug A is more potent than Drug B
d. Drug B is more potent than Drug A
e. None of the above - ✔✔b. Drug B has greater efficacy than Drug A
The TD50 of a drug in rats was found to be 50 milligrams/kilogram. The
ED50 of the same drug in rats was 1 milligram/kilogram. From this
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information, one can calculate that the therapeutic index of the drug in rats
is:
a. 49
b. 0.02
c. 51
d. 500
e. 50 - ✔✔e. 50
The reason for the selective toxicity of sulfanilamide is the following:
a. Susceptible bacteria require folic acid, while the hosts' cells do not
b. Susceptible bacteria synthesize folic acid from asparagine, while the
hosts' cells use preformed folic acid
c. Susceptible bacteria synthesize folic acid from para-aminobenzoic acid
(PABA), while the hosts' cells use preformed folic acid
d. Susceptible bacteria synthesize folic acid from atoxyl, while the hosts'
cells use preformed folic acid
e. Susceptible bacteria synthesize folic acid from para-aminobenzoic acid
(PABA), while the hosts' cells do not utilize folic acid - ✔✔c. Susceptible
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bacteria synthesize folic acid from paraaminobenzoic acid (PABA), while
the hosts' cells use preformed folic acid
Which one of the following statements is correct:
a. Drugs can be dissolved in non-purified water for intravenous injection
b. It is not possible for poisonous materials to be absorbed through the skin
c. Sometimes drugs are given rectally because it always provides the
greatest bioavailability of a drug
d. A good relationship exists between the concentration of drug in the blood
and the concentration of drug at the site of action
e. After injection of drugs into skeletal muscle, the drugs are generally
slowly absorbed into the blood supply of the muscle and usually act after a
period of one hour - ✔✔d. A good relationship exists between the
concentration of drug in the blood and the concentration of drug at the site
of action
Which one of the following statements is correct?
a. The main use of ergonovine today is to induce labour
b. Colchicine, isolated from the Colchium plant, is a valuable drug for the
treatment of rheumatoid arthritis