CGC Exam - Genetics Overview Questions And 100%
Complete Solutions
Chromosomes that assume the shape of an X consist of ___-Answer 2 identical sister
chromatids (this is after DNA replication)
One chromatid is ___ -Answer One half of a replicated chromosome
What percent of DNA is the exome in humans? -Answer 1%
Name the 2 major categories of genetic disorders. -Answer Chromosome abnormalities
& single gene conditions
What does cytogenic/cytogenetic testing look at? -Answer The number and structure of
chromosomes to assess for missing or extra whole chromosomes or pieces of
chromosomes
What are 3 examples of cytogenetic tests? -Answer FISH, karyotype, microarray
What is a microarray used to detect? -Answer Smaller changes that karyotypes do not
have high enough resolution to detect
What do single gene conditions arise from? - Answer DNA sequence variants in a single
gene [example: point mutations, small del/dups]
The presence of a genetic alteration in single gene disorders can usually only be
uncovered with molecular testing because ___ - Answer These changes are too small to
be picked up by a karyotype or microarray
Complete Solutions
Chromosomes that assume the shape of an X consist of ___-Answer 2 identical sister
chromatids (this is after DNA replication)
One chromatid is ___ -Answer One half of a replicated chromosome
What percent of DNA is the exome in humans? -Answer 1%
Name the 2 major categories of genetic disorders. -Answer Chromosome abnormalities
& single gene conditions
What does cytogenic/cytogenetic testing look at? -Answer The number and structure of
chromosomes to assess for missing or extra whole chromosomes or pieces of
chromosomes
What are 3 examples of cytogenetic tests? -Answer FISH, karyotype, microarray
What is a microarray used to detect? -Answer Smaller changes that karyotypes do not
have high enough resolution to detect
What do single gene conditions arise from? - Answer DNA sequence variants in a single
gene [example: point mutations, small del/dups]
The presence of a genetic alteration in single gene disorders can usually only be
uncovered with molecular testing because ___ - Answer These changes are too small to
be picked up by a karyotype or microarray
