Urinalysis and Body Fluids: Chapter 7 Renal
Disease Exam Questions With Solutions
How immunologic disorders damage the glomerulus - Increased serum immunoglobulins
are deposited on the glomerular membranes
- Immune system mediators: complement proteins migrate & produce change & damage to
membranes
Glomerulonephritis (definition) General term for sterile, inflammatory process affecting
the glomerulus
Urinalysis for Glomerulonephritis Hematuria
Proteinuria
RBC casts
Glomerulonephritis progression Acute > Chronic > Nephrotic Syndrome > Renal Failure
Types of Glomerular Disorders (11 Total: 9 Glomerulonephritis & 2 Nephrotic Syndrome)
Glomerulonephritis
1. Acute Poststreptococcal Glomerulonephritis
,Urinalysis and Body Fluids: Chapter 7 Renal
Disease Exam Questions With Solutions
2. Rapidly Progressive (Crescentic) Glomerulonephritis
3. Goodpasture Syndrome
4. Wegener Granulomatosis
5. Henoch-Schönlein Purpura
6. Membranous Glomerulonephritis
7. Membranoproliferative Glomerulonephritis (MPGN)
8. Chronic Glomerulonephritis
9. Immunoglobulin A Nephropathy (Berger Disease)
Nephrotic Syndrome
1. Minimal Change Disease (Lipid Nephrosis)
2. Focal Segmental Glomerulosclerosis (FSGS)
Etiology/Clinical Course: Acute Poststreptococcal Glomerulonephritis (AGN) - Fever,
edema around the eyes, oliguria, proteinuria, & hematuria
- Immune complexes deposit on glomerular membranes
- Group A streptococcal infections from strains with M protein in the cell wall
, Urinalysis and Body Fluids: Chapter 7 Renal
Disease Exam Questions With Solutions
Significant Test: Acute Streptococcal Glomerulonephritis (AGN) - Rapid anti-group A
streptococcal enzyme tests
---> Easier to diagnosis quickly
---> Decline in incidence with use of antibiotics
Etiology/Clinical Course: Rapidly Progressive (Crescentic) Glomerulonephritis - More
serious acute form -> renal failure
- Systemic immune disorder
---> Macrophages damage capillary walls
---> Fibrin: permanent damage to capillary tufts
- Some may have increased fibrin degradation products (FDP), cryoglobulins & IgA immune
complex depositions
UA (similar to AGN):
Progression (more abnormal):
- Elevated Protein
- Low GFR
Disease Exam Questions With Solutions
How immunologic disorders damage the glomerulus - Increased serum immunoglobulins
are deposited on the glomerular membranes
- Immune system mediators: complement proteins migrate & produce change & damage to
membranes
Glomerulonephritis (definition) General term for sterile, inflammatory process affecting
the glomerulus
Urinalysis for Glomerulonephritis Hematuria
Proteinuria
RBC casts
Glomerulonephritis progression Acute > Chronic > Nephrotic Syndrome > Renal Failure
Types of Glomerular Disorders (11 Total: 9 Glomerulonephritis & 2 Nephrotic Syndrome)
Glomerulonephritis
1. Acute Poststreptococcal Glomerulonephritis
,Urinalysis and Body Fluids: Chapter 7 Renal
Disease Exam Questions With Solutions
2. Rapidly Progressive (Crescentic) Glomerulonephritis
3. Goodpasture Syndrome
4. Wegener Granulomatosis
5. Henoch-Schönlein Purpura
6. Membranous Glomerulonephritis
7. Membranoproliferative Glomerulonephritis (MPGN)
8. Chronic Glomerulonephritis
9. Immunoglobulin A Nephropathy (Berger Disease)
Nephrotic Syndrome
1. Minimal Change Disease (Lipid Nephrosis)
2. Focal Segmental Glomerulosclerosis (FSGS)
Etiology/Clinical Course: Acute Poststreptococcal Glomerulonephritis (AGN) - Fever,
edema around the eyes, oliguria, proteinuria, & hematuria
- Immune complexes deposit on glomerular membranes
- Group A streptococcal infections from strains with M protein in the cell wall
, Urinalysis and Body Fluids: Chapter 7 Renal
Disease Exam Questions With Solutions
Significant Test: Acute Streptococcal Glomerulonephritis (AGN) - Rapid anti-group A
streptococcal enzyme tests
---> Easier to diagnosis quickly
---> Decline in incidence with use of antibiotics
Etiology/Clinical Course: Rapidly Progressive (Crescentic) Glomerulonephritis - More
serious acute form -> renal failure
- Systemic immune disorder
---> Macrophages damage capillary walls
---> Fibrin: permanent damage to capillary tufts
- Some may have increased fibrin degradation products (FDP), cryoglobulins & IgA immune
complex depositions
UA (similar to AGN):
Progression (more abnormal):
- Elevated Protein
- Low GFR
