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College aantekeningen Fysiologie hc2

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Dit is een samenvatting van hoorcollege 2. Dit college wordt gegeven in blok 1, gezondheid. Het college gaat over spierbouw en spieractiviteit

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October 24, 2024
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October 24, 2024
Number of pages
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2024/2025
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Hoorcollege 2, spierbouw en spieractiviteit

Van macro naar microniveau (spieren)

Spiervezel:
1. Spierfascie
2. Spierbundels
3. Spiervezels




Dwarsdoorsnede spiervezel.

• Sarcolemma: spiervezelmembraan
• Celkern (bruin) – bestuurd cel + maakt eiwitten aan.
• Mitochondriën (geel) – energiecentrale van de cel. ATP opbouwen (ATP= brandstof)
• Myofibrillen.
• Sarcotubulaire systeem (lichtblauw) – stuurt signalen door.

Myo = spier
Fibrillen = draad

In spiervezel zitten:
- Myofibrillen.

In myofibrillen zitten:
- Actine
- Myosine

Actine – dunne draadjes
Myosine – dikkere draadjes

Actine en myosine zorgen voor contractie.
• Spier verkorten? Draadjes gaan dan in elkaar.

Actine draadje bestaat uit bolvormige eiwitmolecule die aan elkaar gekoppeld zijn.
Aan actine zitten bindingsdraadjes van myosine.

, Myosine in elkaar gedraaide structuur met daaraan 2 koppen. Staart die in elkaar gedraaid is
zijn myosine koppen. Daarmee kan hij koppelen aan actine.

Myosine ligt om de actinefillamenten heen.




Actine




Myosine




• Klein stukje koppelen? Minder kracht uitoefenen.
• Veel overlap = meer kracht.
• Spier wordt korter als in elkaar schuift.

Z-lijn naar volgende Z-lijn = sarcomeer

- Spiervezel vormt samen 1 grote spier.
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