ATI Pharmacology Cardiovascular
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Furosemide (Lasix)
✓ High Ceiling Loop Diuretic; work in the ascending loop of henle. Block reabsorption of
sodium and chloride and to prevent reabsorption of water.
Furosemide (Lasix) therapeutic use
✓ used when there is an emergent need for rapid mobilization of fluid. Pulmonary edema
caused by heart failure. Treats hypercalcemia.
Hydrochlorothiazide (Hydrodiuril)
✓ Thiazide diuretic; work in early distal convoluted tubule; blocks reabsorption of sodium
and chloride, and thus prevents reabsorption of water. Promotes diuresis.
Hydrochlorthiazide (Hydrodiuril) therapeutic use
✓ first choice for essential hypertension. Used for edema of mild-to-moderate heart failure
and liver and kidney disease. Used with antihypertensive agents for blood pressure
control.
Mannitol (Osmitrol)
✓ Osmotic diuretic; reduce intracranial pressure and intraocular pressure by raising serum
osmolality and drawing fluid back in to the vascular and extravascular space.
Mannitol (Osmitrol) therapeutic uses
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✓ prevent kidney failure, such as hypovolemic shock and severe hypotension. Decreases IOP
and ICP. Promote sodium retention and water excretion in clients who have hyponatremia
and fluid volume excess.
Captopril (capoten)
✓ ACE inhibtor; block the conversion of angiotensin I to angiotensin II leading to
vasodilation, excretion of water and sodium, and retention of potassium.
Thiazide diuretics
✓ often first medication given for hypertension.
ACE inhibitors
✓ hypertension, heart failure, myocardial infarction. Adverse effects: first dose orthostatic
hypotension, cough, hyperkalemia, rash and altered taste, angioedema, neutropenia.
Angiotensin II receptor blockers (ARBs)
✓ Losartan (Cozaar); blocks action of angiotensin II in the body. Results in vasodilation;
excretion of sodium and water, and retention of potassium.
Losartan (Cozaar) adverse effects
✓ Angioedema and fetal injury.
Aldosterone antagonists
✓ eplerenone (Inspra) and spironolactone (Aldactone); reduce blood volume by blocking
aldosterone receptors in the kidney. Used for hypertension and heart failure.
Aldosterone antagonist adverse effects
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