ALL NBME review Exam Questions and Answers

ALL NBME review Exam Questions and
Answers

TRYPTASE iiMAST iiCELL

TRYPSIN iiPANCREAS ii- iiAnswers ii-Tryptase iiMast iiCell iiSpecific
marker iimast iicell iiactivation
type ii1 iihypersensitvity iiuriticaria
angioedema iivisceral iiedema iihypotension

Length iiConstant ii= iiMyelination ii- iiAnswers ii-Demylination iiin iiMS iiDecreases iiLength
iiConstant


A-Delta iiFibers
thin iimyelinated iifibers ii- iiAnswers ii-Thin iiMyelinated iiNerve iiFibers
Detect iiTemperature ii+ iiNociceptive

GTO ii1B
extrafusal iifibers ii- iiAnswers ii-Series iiConnection ii
Increase iiTension iitransmit iivia iiGTO
1b iicontact iiinhibitory iiinterneuron
Prevents iidamage iito iiMSK

Red iifacial iilesion iipersist iiinto iiadulthood

different iifrom iistrawberry iihemangioma iiwill iiregress ii- iiAnswers ii-Sturge iiWeber
iiDisease
Leptomeningeal iiAngiomatosis

CT: iiHemispheric iiAtrophy iidue iito iiVenous iiInfarction iiTram-Track iiCalcification

Chromosome ii10 ii- iiAnswers ii-C-Cell iiCarcinoma

BACLOFEN

Skeletal iiMuscle iiRelaxant

Side iiEffects: ii
Hypotension
Drowsy iiFatigue ii- iiAnswers ii-inhibits iimono iipoly iisynaptic iireflex ii@ iispinal iicord

,Treat: ii
1) iiMS iiSpasticity ii
2) iiSpinal iiCord iiSpasticity
3) iiTrigeminal iiNeuralgia

Solar iiElastosis
Actinic iiKeratoses ii- iiAnswers ii-Elastin iiin iiDermis- iiDamaged

Neutrophil iiin iiS. iiCorneum= iiMunro iiAbscesses

Psoriasis ii- iiAnswers ii-Neutrophil iiStratum iiCorneum

Dermis: iiimagine iineutrophil ii+ iieosinophils

dermatitis iiherpetiformis ii- iiAnswers ii-

- iiGranulomas ii: iisecrete iiIFN-Y
- iiIFN-Y: iiactivates iimacrophage
-macrophage: iiincrease ii1-a iihydroxylase
-1-a iihydroxylase: iiincrease iiactive iivitamin iiD ii=)

High iiCalcium iiLow iiPTH ii- iiAnswers ii-GRANULOMATOUS iiDISEASES ii+ iiCALCIUM
iiLEVELS


1) iiSarcoidosis
2) iiHodgkin iiLymphoma

1) iiMetastasis iiCancer iiCells
2) iiCytokines ii
3) iiChemokines
4) iiPTHrP ii- iiAnswers ii-HyperCalcemia iiCauses

Necrotizing iiFascitis ii- iiAnswers ii-1. iiFever iiHypotension
2. iiPain iiout iiof iiProportion

-Strep iiPyogenes
-Staph iiAureus
- iiC. iiPerfringens

Tyrosine iiKinase

1) iiInsulin
2) iiIGF-1
3) iiCytokines ii- iiAnswers ii-Insulin iiIGF-1 iiCytokines

Hydrophobic iiAA iispan iitransmembrane: iivaline iialanine iimethionine iiisoleucine

,INSULIN

Tyrosine iiPhosphorylates iiIRS

IRS iiPhosphoryl: ii2 iiPathways ii- iiAnswers ii-IRS iiundergoes ii1) iior iipathway ii2)

1) ii
Tyrosine iiAutoPhosphorylates
MAP-phosphorylates iiRAS
Goal: iiCell iiGrowth iiDNA iiSynthesis

2) ii
Multiple iiSignals
PI3K iiPathway: iiGLUT4 iiTransport=)
Goal: iiglucose iitransport, iilipid, iiprotein iisynthesis

Histidinemia ii- iiAnswers ii-A.R. iiHistidase iiDeficiency
Psychomotor iiRetardation
Emotional iiDisturbance

AA iiwith ii3 iititrate iiprotons ii- iiAnswers ii-Histidine
Arginine
Lysine
Aspartic iiAcid
Glutamic iiAcid
Tyrosine

1) iiCleaves iiPhospholipid ii

2) iiMessenger iiof iiIP3 iiand iiDAG ii- iiAnswers ii-1) iiLipid iicleaved iiby iiPLC

2) iiSecondary iiMsgr iiis iiPKC iiof iiboth

1) iiPFK-1 ii

2) iiF iiBisPhosphatase ii1

3) iiFastest iiSugar iiDigested ii- iiAnswers ii-1) iiGlycogenesis iiUsed

2) iiGluconeogenesis iiused

3) iiFructose iiis iifastest! iibypasses iithe iiPFK-1 iirate iilimiting iistep

Aberrant iiSerine iiThreonine iiPhosphorylation ii- iiAnswers ii-INSULIN iiRESISTANCE

, Serine iiThreonine iiPhosphorylated iinormal iiinsulin iireceptor iibefore iiTyrosine iiKinase
iidoes


Abberant iiPhosphorylation:
1) iiTNF-a ii2) iiCatecholamine ii
3) iiGlucocorticoids ii4) iiGlucagon

PDGF ii- iiAnswers ii-PDGF iiSecreted iiBy:
1) iiadherent iiplatelets
2) iiendothelial iicells
3) iimacrophages
-promotes iismooth iimuscle iicell iimigration iifrom iimedia iito iiintima
-subsequent iiproliferation

Thickening iiand iiCollagen iiDeposition ii- iiAnswers ii-Smooth iiMuscle iiCells: iiVCAM-1

TRIMETHAPHAN ii- iiAnswers ii-Mecamylamine
Hexamethonium ii

All iiGanglion iiBlockers!

Classic iicomplement iipathway iibegins iiwith iiwhich iicomponents? ii- iiAnswers ii-Antigen-
antibody iicomplexes ii+ iiC1

Lectin iicomplement iipathways iibegins iiwith iiwhich iicomponents? ii- iiAnswers ii-Microbial
iisurfaces ii(e.g., iimannose) ii+ iimannose-binding iiligand ii(forms iiC1-like iicomplex) ii+ iiC4


What iiconvertase iiis iishared iiby iithe iilectin iiand iiclassical iipathways? ii- iiAnswers ii-
C4b2b ii(aka iiC3 iiconvertase)

What iiinitiates iithe iialternative iipathway ii- iiAnswers ii-Spontaneous iiand iimicrobial
iisurfaces ii+ iiC3


What iiis iithe iiunique iiconvertase iiused iiby iithe iialternative iipathway? ii- iiAnswers ii-
C3bBb ii(aka iiC3 iiconvertase)

Deficiency iithat iiincreases iisusceptibility iito iitype iiIII iihypersensitivity ii- iiAnswers ii-C3
iideficiency ii(this iiis iibecause iiC3*a* ii[not iiC3b] iiaids iiin iithe iiclearance iiof iiimmune
iicomplexes)


Oprelvekin ii- iiAnswers ii-IL-11 iiRecombinant iicytokine
Indicatd iifor iithrombocytopenias ii(as iiis iithrombopoietin)

Identify iitarget iiof iifollowing:
Alemtuzumab
Bevacizumab