MCB Exam 2 Rats Questions and
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Extensive digestion of chromatin with micrococcal nuclease was found to
yield particles called nucleosome core particles that appear as beads when
viewed by electron microscopy. Which of the following is not found in the
nucleosome core particle?
a. Two molecules of H2A protein
b. Two molecules of H3 protein
c. Two molecules of H4 protein
d. One molecule of H1 protein - ✔✔d. One molecule of H1 protein
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The transfer of information from parent to progeny that is not based on
DNA sequences is known as
a. epigenetic inheritance.
b. non-Mendelian genetics.
c. sex-linked inheritance.
d. Mendelian genetics. - ✔✔a. epigenetic inheritance.
In the chromatin around centromeres, nucleosomes are present that have a
unique structure in which the core protein _______ is replaced by _______,
and this variant of the nucleosome is required for protein assembly at the
kinetochore.
a. histone H3; CENP-A
b. histone H3; histone H5
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c. histone H1; CENP-A
d. histone H1; histone H5 - ✔✔a. histone H3; CENP-A
During metaphase in actively dividing cells, DNA is in
a. heterochromatin.
b. nucleoli.
c. chromosomes.
d. euchromatin. - ✔✔c. chromosomes.
A centromere is a
a. region of euchromatin devoid of histones.
b. sequence at the end of chromatids.
c. region where proteins bind to form kinetochores.
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d. specific, repeated DNA sequence. - ✔✔c. region where proteins bind to
form kinetochores.
Heterochromatin gets its name from the fact that it contains a mixture of
active and inactive genes.
True or False - ✔✔False
The function of telomeres is to
a. condense the chromosomes in preparation for mitosis.
b. ensure chromosome replication and maintenance.
c. hold the sister chromatids together and bind the spindle during mitosis.
d. provide a binding site for DNA polymerase to initiate replication. - ✔✔b.
ensure chromosome replication and maintenance.
Interaction between the finger-like projections of histones with DNA is
based on a charge attraction