Pathoma-Questions and Answers 100% Solved

Pathoma-Questions and Answers 100% Solved

Heparin-Induced Thrombocytopenia Correct Ans-Platelet destruction that arises secondary
to heparin therapy




Disseminated Intravascular Coagulation (DIC) Correct Ans-Pathologic activation of the
coagulation cascade




Anemia Correct Ans-Disruption in circulating red blood cell (RBC) mass




Anemia of Chronic Disease Correct Ans-Anemia associated with chronic inflammation or
cancer




Iron Deficiency Anemia Correct Ans-Anemia due to decreased levels of iron




Sideroblastic Anemia Correct Ans-Anemia due to defective protoporphyrin synthesis




Thalassemia Correct Ans-Anemia due to decreased synthesis of the globin chains of
hemoglobin




Megaloblastic Anemia Correct Ans-Anemia due to folate or vitamin B12 deficiency

, Pathoma-Questions and Answers 100% Solved
Hereditary Spherocytosis Correct Ans-Inherited defect of RBC cytoskeleton-membrane
tethering proteins




Sickle Cell Anemia Correct Ans-Autosomal recessive mutation in beta chain of hemoglobin;
a single amino acid change replaces normal glutamic acid (hydrophilic) with valine
(hydrophobic)




Paroxysmal Nocturnal Hemoglobinuria (PNH) Correct Ans-Acquired defect in myeloid stem
cells resulting in absent glycosylphosphatidylinositol (GPI); renders cells susceptible to
destruction by complement




Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency Correct Ans-X-linked recessive
disorder resulting in reduced half-life of G6PD; renders cells susceptible to oxidative stress




Immune Hemolytic Anemia Correct Ans-Antibody-mediated (IgG or IgM) destruction of
RBCs




Microangiopathic Hemolytic Anemia Correct Ans-Intravascular hemolysis that results from
vascular pathology; RBCs are destroyed as they pass through the circulation




Malaria Correct Ans-Infection of RBCs and liver with Plasmodium; transmitted by the
female Anopheles mosquito

, Pathoma-Questions and Answers 100% Solved
Parvovirus B19 Correct Ans-Infects progenitor red cells and temporarily halts
erythropoiesis; leads to significant anemia in the setting of preexisting marrow stress (e.g.,
sickle cell anemia)




Aplastic Anemia Correct Ans-Damage to hematopoietic stem cells, resulting in
pancytopenia (anemia, thromobocytopenia, and leukopenia) with low reticulocyte count




Infectious Mononucleosis Correct Ans-EBV infection that results in a lymphocytic
leukocytosis comprised of reactive CD8+ T cells; CMV is a less common cause




Acute Lymphoblastic Leukemia (ALL) Correct Ans-Neoplastic accumulation of lymphoblasts
(>20%) in the bone marrow




Acute Myeloid Leukemia (AML) Correct Ans-Neoplastic accumulation of myeloblasts
(>20%) in the bone marrow




Chronic Lymphocytic Leukemia (CLL) Correct Ans-Neoplastic proliferation of naive B cells
that co-express CD5 and CD20




Hairy Cell Leukemia Correct Ans-Neoplastic proliferation of mature B cells characterized by
hairy cytoplasmic processes

, Pathoma-Questions and Answers 100% Solved
Adult T-Cell Leukemia/Lymphoma (ATLL) Correct Ans-Neoplastic proliferation of mature
CD4+ T cells




Mycosis Fungoides Correct Ans-Neoplastic proliferation of mature CD4+ T cells that
infiltrate the skin, producing localized skin rash, plaques, and nodules




Chronic Myeloid Leukemia (CML) Correct Ans-Neoplastic proliferation of mature myeloid
cells, especially granulocytes and their precursors; basophils are characteristically increased




Polycythemia Vera (PV) Correct Ans-Neoplastic proliferation of mature myeloid cells,
especially RBCs




Essential Thrombocytopenia Correct Ans-Neoplastic proliferation of mature myeloid cells,
especially platelets




Myelofibrosis Correct Ans-Neoplastic proliferation of mature myeloid cells, especially
megakaryocytes




Follicular Lymphoma Correct Ans-Neoplastic proliferation of small B cells (CD20+) that
form follicle-like nodules




Mantle Cell Lymphoma Correct Ans-Neoplastic proliferation of small B cells (CD20+) that
expands the mantle zone