ATI: GI system PME
Histamine H2 Antagonists expected action - correct answer ✔✔Block the histamine receptors in the
stomach that are responsible for the secretion of stomach acid
- block the receptors located on the parietal cells in the stomach, decreasing the amount of stomach acid
produces and increasing the pH of stomach acid
Histamine H2 Antagonists adverse reactions: - correct answer ✔✔Impotence, gynecomastia, and
reduced libido - side effects with cimetidine
Confusion, arrhythmias, agranulocytosis and aplastic anemia
administration histamine H2 antagonist - correct answer ✔✔PO, IM, IV
Give with/without food
Admin IV slowly to avoid bradycardia
Do not give antacids within 1 hour of admin
Histamine H2 Antagonist prototypes - correct answer ✔✔Cimetidine
- also called Tagamet
Others: famotidine (Pepcid), and nizatidine (Axed)
Proton pump inhibitors (PPIs) prototypes - correct answer ✔✔Omeprazole (Prilosec)
Pantoprazole (Protonix)
Lansoprazole (Prev acid)
Esomeprazole (Nexium)
Histamine H2 Antagonists expected action - correct answer ✔✔Block the histamine receptors in the
stomach that are responsible for the secretion of stomach acid
- block the receptors located on the parietal cells in the stomach, decreasing the amount of stomach acid
produces and increasing the pH of stomach acid
Histamine H2 Antagonists adverse reactions: - correct answer ✔✔Impotence, gynecomastia, and
reduced libido - side effects with cimetidine
Confusion, arrhythmias, agranulocytosis and aplastic anemia
administration histamine H2 antagonist - correct answer ✔✔PO, IM, IV
Give with/without food
Admin IV slowly to avoid bradycardia
Do not give antacids within 1 hour of admin
Histamine H2 Antagonist prototypes - correct answer ✔✔Cimetidine
- also called Tagamet
Others: famotidine (Pepcid), and nizatidine (Axed)
Proton pump inhibitors (PPIs) prototypes - correct answer ✔✔Omeprazole (Prilosec)
Pantoprazole (Protonix)
Lansoprazole (Prev acid)
Esomeprazole (Nexium)
