Chapter 6: Mechanisms of Disease
Monday, February 3, 2020 12:10 PM
Homeostasis
- Maintaining a stable internal environment or internal balance
- Vital to an organisms health and survival
Disease
- Inability to maintain homeostasis
- Failure of feedback loops
- An abnormality in body function that threatens health
○ "lack of ease"
○ Disturbance threatening well-being
Understanding a Disease
- Is a science
- Grounded in observations, theories and experiments via scientific method
- Evaluation and treatment needs to be evidence based
Disease Terminology
Etiology: study of the factors that cause a disease
, Idiopathic: unknown cause of disease
Signs and Symptoms: presentation of the disease (subjective [what patient tells you] and o
[physical exams, doctors findings])
Pathogenesis: pattern of a disease's development
Disease Progression
Acute: signs and symptoms come on quickly and last a short time
Chronic: comes on slowly and lasts a long time
Morbidity: disability due to a disease
Morality: Terminal
Patterns of Disease
Epidemiology: the study of occurrence distribution, and transmission of diseases in human
populations
Epidemics: disease affecting many people, locally at the same time
Endemic diseases: native to a local region or people
Endemic
- Tay Sachs Disease
○ Fatal
○ 1:30 with Ashkenazi Jewish heritage (carriers)
P d fh (d f l k f
Monday, February 3, 2020 12:10 PM
Homeostasis
- Maintaining a stable internal environment or internal balance
- Vital to an organisms health and survival
Disease
- Inability to maintain homeostasis
- Failure of feedback loops
- An abnormality in body function that threatens health
○ "lack of ease"
○ Disturbance threatening well-being
Understanding a Disease
- Is a science
- Grounded in observations, theories and experiments via scientific method
- Evaluation and treatment needs to be evidence based
Disease Terminology
Etiology: study of the factors that cause a disease
, Idiopathic: unknown cause of disease
Signs and Symptoms: presentation of the disease (subjective [what patient tells you] and o
[physical exams, doctors findings])
Pathogenesis: pattern of a disease's development
Disease Progression
Acute: signs and symptoms come on quickly and last a short time
Chronic: comes on slowly and lasts a long time
Morbidity: disability due to a disease
Morality: Terminal
Patterns of Disease
Epidemiology: the study of occurrence distribution, and transmission of diseases in human
populations
Epidemics: disease affecting many people, locally at the same time
Endemic diseases: native to a local region or people
Endemic
- Tay Sachs Disease
○ Fatal
○ 1:30 with Ashkenazi Jewish heritage (carriers)
P d fh (d f l k f
