Test Bank Solution Manual for Blood Bank Chapter 20 Rated 100%

Test Bank Solution Manual for Blood Bank Chapter 20 Rated 100% Immune hemolytic anemias may be classified in which of the following categories? a. Alloimmune b. Autoimmune c. Drug-induced d. All of the above - Answers D - All of the above When preparing cells for a cold autoadsorption proce- dure, it is helpful to pretreat the cells with which of the following? a. Dithiothreitol b. Ficin c. Phosphate-buffered saline at pH 9 d. Bovine albumin - Answers B - Ficin The blood group involved in the autoantibody specificity in PCH is: a. P b. ABO c. Rh d. Lewis - Answers A - P Which of the following blood groups reacts best with an anti-H or anti-IH? a. O b. B c. A2 d. A1 - Answers A - O With cold reactive autoantibodies, the protein coating the patient's cells and detected in the DAT is: a. C3 b. IgG c. C4 d. IgM - Answers A - C3 Problems in routine testing caused by cold reactive autoantibodies can usually be resolved by all of the following except: a. Prewarming b. Washing with warm saline c. Using anti-IgG antiglobulin serum d. Testing clotted blood specimens - Answers D - testing clotted blood specimens Pathological cold autoagglutinins differ from common cold autoagglutinins in: a. Immunoglobulin class b. Thermal amplitude c. Antibody specificity d. DAT results on EDTA specimen - Answers B - Thermal amplitude Cold AIHA is sometimes associated with infection by: a. Staphylococcus aureus b. Mycoplasma pneumoniae c. Escherichia coli d. Group A Streptococcus - Answers B M. pneumonia Many warm reactive autoantibodies have a broad specificity within which of the following blood groups? a. Kell b. Duffy c. Rh d. Kidd - Answers C- Rh Valid Rh typing can usually be obtained on a patient with WAIHA using all of the following reagents or techniques except: a. Slide and modified tube anti-D b. Chloroquine-treated RBCs c. Rosette test d. Monoclonal anti-D - Answers A - Slide and modified tube anti-D In pretransfusion testing for a patient with WAIHA, the primary concern is: a. Treating the patient's cells with chloroquine for reliable antigen typing b. Adsorbing out all antibodies in the patient's serum to be able to provide compatible RBCs c. Determining the exact specificity of the autoantibody so that compatible RBCs can be found d. Discovering any existing significant alloantibodies in the patient's circulation - Answers D - Discovering any existing significant alloantibodies in the patient's circulation Penicillin given in massive doses has been associated with RBC hemolysis. Which of the classic mechanisms is typically involved in the hemolytic process? a. Immune complex b. Drug adsorption c. Membrane modification d. Autoantibody formation - Answers B - Drug absorption Which of the following drugs has been associated with complement activation and rapid intravascular hemoly- sis? a. Penicillins b. Quinidine c. Alpha-methyldopa d. Cephalosporins - Answers D - Cephalosporins A patient is admitted with a hemoglobin of 5.6 g/dL. Initial pretransfusion workup appears to indicate the presence of a warm autoantibody in the serum and coat- ing his RBCs. His transfusion history indicates that he received 6 units of RBCs 2 years ago after an automobile accident. Which of the following would be most helpful in performing antibody detection and compatibility testing procedures? a. Adsorb the auto antibody using the patient's enzyme- treated cells. b. Perform an elution and use the eluate for compatibil- ity testing. c. Crossmatch random units until compatible units are found. d. Collect blood from relatives who are more likely to be compatible. - Answers A - Adsorb the auto antibody using the patient's enzyme- treated cells A patient who is taking Aldomet has a positive DAT. An eluate prepared from his RBCs would be expected to: a. React only with Aldomet-coated cells b. Be neutralized by a suspension of Aldomet c. React with all normal cells d. React only with Rhnull cells - Answers C - React with all normal cells One method that can be used to separate a patient's RBCs from recently transfused donor RBCs is: a. Chloroquine diphosphate treatment of the RBCs b. Reticulocyte harvesting c. EGA treatment d. Donath-Landsteiner testing - Answers B - Reticulocyte harvesting Monoclonal antisera is valuable in phenotyping RBCs with positive DATs because: a. Both polyspecific and monospecific antihuman serum can be used in antiglobulin testing b. Anti-C3 serum can be used in antiglobulin testing c. It usually does not require antiglobulin testing d.It does not require enzyme treatment of the cells prior to antiglobulin testing - Answers C - It usually does not require antiglobulin testing Autoadsorption procedures to remove either warm or cold autoantibodies should not be used with a recently transfused patient. Recently means: