PCB 3233 Exam 6 Study Guide Chapter
13
Which T-cells decline in an HIV patient? What is the significant # of those cells for a transition to AIDs? -
correct answer ✔✔CD4 T cells decline in an HIV patient.
Once your T cell count falls below 200/ul it results in AIDs.
Know gp 120 and 41 and what they do? What is the precursor polypeptide these are created from? -
correct answer ✔✔Binding and fusion of HIV into a target cell takes place by interaction with 2
membrane glycoproteins.
Gp120 = Binding
Gp41 = Fusion
Gp160 gives rise to Gp120 and Gp41.. Slide 34
What are tat, rev, protease, integrase and reverse transcriptase and what is the function of each? are all
of these premed by the virus when it infects the cell or are some made after the cell is infected? Which
ones have to be made after infection? - correct answer ✔✔Tat = binds to transcription activation region
of viral mRNA and prevents transcription from shutting off.
Rev = controls the supply of viral RNA to the cytoplasm; it deliver RNA that encodes the proteins
necessary to make visions.
Integrase = integrate the cDNA into the host's genome to form provirus
Reverse Transcriptase = Copies the viral RNA genome into double stranded cDNA.
The ones that need to be made after the infection are gag, pol, and env.
How many RNA molecules make up HIV genome? How many make up influenza's genome? - correct
answer ✔✔Influenza = 8 RNA molecules
HIV =
What is Lymphocyte tropic vs Macrophage tropic (HIV)? Which co-receptors are associated with each?
Which is associated with early infection and which is associated with late infection? Which is associated
13
Which T-cells decline in an HIV patient? What is the significant # of those cells for a transition to AIDs? -
correct answer ✔✔CD4 T cells decline in an HIV patient.
Once your T cell count falls below 200/ul it results in AIDs.
Know gp 120 and 41 and what they do? What is the precursor polypeptide these are created from? -
correct answer ✔✔Binding and fusion of HIV into a target cell takes place by interaction with 2
membrane glycoproteins.
Gp120 = Binding
Gp41 = Fusion
Gp160 gives rise to Gp120 and Gp41.. Slide 34
What are tat, rev, protease, integrase and reverse transcriptase and what is the function of each? are all
of these premed by the virus when it infects the cell or are some made after the cell is infected? Which
ones have to be made after infection? - correct answer ✔✔Tat = binds to transcription activation region
of viral mRNA and prevents transcription from shutting off.
Rev = controls the supply of viral RNA to the cytoplasm; it deliver RNA that encodes the proteins
necessary to make visions.
Integrase = integrate the cDNA into the host's genome to form provirus
Reverse Transcriptase = Copies the viral RNA genome into double stranded cDNA.
The ones that need to be made after the infection are gag, pol, and env.
How many RNA molecules make up HIV genome? How many make up influenza's genome? - correct
answer ✔✔Influenza = 8 RNA molecules
HIV =
What is Lymphocyte tropic vs Macrophage tropic (HIV)? Which co-receptors are associated with each?
Which is associated with early infection and which is associated with late infection? Which is associated
