Questions with complete solutions
2024/2025
Treacher Collins Syndrome - correct answer 1st arch neural
crest fails to migrate > mandibular hypoplasia, facial
abnormalities. Chew
2nd branchial arch - correct answer "S" structures, CN VII.
Smile
3rd arch - correct answer stylopharyngeous, glossopharyngeal
muscle, CN IX. Swallow Stylishly
4th -6th arches - correct answer cartilages: thyroid,
crycothyroid, arytenoids, corniculate, cuneiform. 4th arc CN X
superior laryngeal branch (simply Swallow). 6th arch CN X
recurrent laryngeal (speak).
branchial arches - correct answer When at the restaurant of
golden Arches, children's tend to first Chew (1st), then Smile
(2nd), then Swallow stylishly (3rd) or Simply swallow (4th), and
then Speak (6th).
STURGE-Weber syndrome - correct answer Sporadic, port-
wine Stain, Tram-Track Ca+, Unilateral Retardation, Glaucoma,
GNAQ gene, Epilepsy.
,glioblastoma multiforme (grade IV astroctoma) - correct answer
Adult. common highly malignant 1mary brain tumor found in
cerebral hemispheres. stain for GFAP "pseudopalisading"
meningioma - correct answer Adult. common typically benign
brain tumor. spindle cells concentrically arranged in a whole
patter; psammoma bodies.
hemangioblastoma - correct answer Adult. most often
cerebellar. associated with VHL syndrome when foun in retinal
angiomas. can produce erythropoietin > 2ndary polycytemia
schwannoma - correct answer Adult. usually found at
cerebellapontine angle. schwann cell origin, S-100+, often
localized to CN VIII > acustic schwanoma. bilateral associated
with NF-2
olidodendroglioma - correct answer Adult. most often in
frontal lobe, chicken wire capillary pattern. fried egg cells
pattern.
pilocystic astroytoma - correct answer usually well-
circumscribed. in children, most often found in posterior fossa.
may be supratentorial. GFAP+. benign good prognosis. Rosenthal
Fibers-eosinophilic, corkscrew fibers.
Medulloblastoma - correct answer highly malignant cerebellar
tumor. A form of primitive neruroectodermal tumor. can
compress 4th ventricle causing drop metastasis to spinal cord.
Homer-Wright rosettes. Solid, small blue cells. sheets of primitive
cells and many mitotic figures. posterior fossa mass
, Ependymoma - correct answer ependymal cells tumors most
commonly found in 4th ventricle, causing hydrocephalus. poor
prognosis. characteristic perivascular rosettes. rod-shaped
blepharoblast. found near nucleus.
Rhomboid crystals, positively birefringent - correct answer
Pseudogout (calcium pyrophosphate dihydrate crystals)
Needle-shaped, negatively birefringent crystals - correct
answer Gout (monosodium urate crystals)
"Spikes" on basement membrane, "dome-like" subepithelial
deposits - correct answer Membranous glomerulonephritis
(may progress to nephrotic yndrome)
"Soap bubble" in femur or tibia on x-ray - correct answer Giant
cell tumor of bone (generally benign)
Lac Operon - correct answer Glucose induce decrease
adenylate cyclase activity leads to low intracellular
concentrations of cAMP. Low cAMP levels, in turn, cause poor
binding of catabolite activation protein (CAP) to the CAP-DNA
binding domain, leading to decreased expression of the
structural genes of the lac operon.
Lac Operon - correct answer The lac operon is regulated by
two distinct mechanism: negatively by binding of the repressor
protein to the operator locus and positively by cAMP-CAP binding
upstream from the promoter region. Constitutively expression of