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Exam (elaborations)

NURSING PHARMACOLOGY MODULE 1

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NURSING PHARMACOLOGY MODULE 1 0 a. Absorption - ANSWERS-the process by which drug molecules move from their site of administration to the blood b. Affinity - ANSWERS-the ability of some tissues to attract, accumulate and store drugs in high concentrations relative to other tissues c. Blood-brain barrier - ANSWERS-Blood vessels (capillaries) that selectively let certain substances enter the brain tissue and keep other substances out d. Diffusion - ANSWERS-process by which molecules tend to move from an area where they are more concentrated to an area where they are less concentrated e. Distribution - ANSWERS-the transport of drugs throughout the body after they are absorbed f. Drug-protein complexes - ANSWERS-formed when a drugh that binds reversibly to a plasma protein, particularly albumin, that makes the drug unavailable for distribution to its site of action g. Enterohepatic recirculation - ANSWERS-recycling of drugs and other substances by the circulation of bile through the intestine and liver h. Enzyme induction - ANSWERS-process by whick a drug increases the activity of the hepatic microsomal enzymes i. Excretion - ANSWERS-the process of removing substances from the body j. First-pass effect - ANSWERS-mechanism whereby drugs are absorbed enter into the hepatic portal circulation and are inactivated by the liver before they reach the general circulation k. Fetal-placental barrier - ANSWERS-special anatomic barrier that inhibits many chemicals and drugs from entering the fetus l. Hepatic microsomal enzyme system - ANSWERS-as it relates to phamacotherapy, liver enzymes that metabolize drugs as well as nutrients and other endogenous substances, sometimes called the P-450 System m. Isozymes - ANSWERS-multiple similar forms of an enzyme that perform slightly different metabolic functions n. Loading dose - ANSWERS-relatively large dose of a drug given at the beginning of treatment to rapidly obtain a therapeutic response o. Maintenance doses - ANSWERS-amount of drug that keeps the plasma drug concentration in the therapeutic range p. Metabolism - ANSWERS-the process used by the body to chemically change a drug molecule, also called biotransformation q. Minimum effective concentration - ANSWERS-amount of drug required to produce a therapeutic effect r. Pharmacokinetics - ANSWERS-study of drug movement throughout the body s. Plasma half-life - ANSWERS-the length of time required for the plasma concentration of a drug to decrease by one half after administration t. Prodrugs - ANSWERS-drugs that become more active after they are metabolized

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NURSING PHARMACOLOGY (DRUGS)
Albuterol - ANSWERS-(SABA) short acting beta 2 receptor agonist, used for
bronchospasm, acute symptoms of asthma

Acetaminophen - ANSWERS-centrally acting cox inhibitor; analgesic and
antipyretic properties; no antiinflammatory,antirheumatic properties

Acyclovir - ANSWERS-Antimetabolite for Treating Herpes Simplex Virus &
Varicella-Zoster Virus Infections;
Moas: Purine necleoside analog: DNA polymerase inhibitor, suppresses synthesis
of viral DNA, resistance.

Amiodarone - ANSWERS-Class 3 Potassium channel blocker
Only approved for life-threatening dysrhythmias.
Delays repolarization and extends action potential of heart muscle cells.
SE: Profound hypotension."

Amoxicillin - ANSWERS-Broad-spectrum penicillin active against H. Influenzae, E.
Coli, and N. Gonorrhoeae. It is inactivated by beta-lactamases, so not helpful for
Staphylococcus.

Atropine - ANSWERS-muscinarinic receptor antagonist/anticholinergic drug; used
for mydriases (eye exams), to raise HR, lower GI motility, and as antidote to
muscarinic poisoning (rx, shrooms)

Amphotericin B - ANSWERS-broad spectrum antifungal, which is the agent of
choice for systemic mycoses, despite being highly toxic. Its uses are limited to
treating progressive and potentially fatal infections. Adverse effects include
infusion reactions, nephrotoxicity, and hypokalemia.

Aspirin - ANSWERS-A drug that decrease platelet aggregation and is used to
prevent arterial thrombosis, stroke, or MI. Major ses include risk of major GI

, bleeding. This drug is an NSAID that works by inhibiting platelet COX, COX-1, and
COX-2.

Beclomethasone - ANSWERS-inhaled corticosteroid used to treat airway
inflammation in asthma

Bethanechol - ANSWERS-muscarinic agnonist, used primarily for urinary retention

Buproprion - ANSWERS-(DA and NE). Weight loss, seizure, insomnia, headache,
serotonin syndrome (see laundry list above), withdrawal, Neonatal Abstinence
Syndrome

Captopril - ANSWERS-ACE inhibitor - shown to have efficacious effects in treating
a patient with heart failure. Blocks production of angiotensin II, dilates arterioles
and veins, and decreases release of aldosterone. It may show the adverse effects
of hypotension, hyperkalemia, or persistant cough, CARDIAC REMODELING

Carbenicillin - ANSWERS-"Extended spectrum (antipseudomonal penicillins),
which has the same spectrum of activity as broad-spectrum penicillins, plus
treatment of Pseudomonas aeruginosa

Cefotaxime - ANSWERS-"Third generation cephalosporin with activity against
meningitis and nosocomial infections resistant to others (restricted use). It has
greater activity against Gram negative bacteria, increased resistance to beta-
lactamases, and better ability to reach CSF.

Cephalexin - ANSWERS-"First generation cephalosporin poor activity against Gram
negative bacteria, sensitive to to most beta-lactamases, unable to reach CSF.
Used for Staphylococcus if mild penicillin allergy.

Celecoxib - ANSWERS-2nd Generation Nonsteroidal Antiinflammatory Drug (COX-
2 Selective NSAID); AE: risk of CV events, warfarin may be more effective with
celecoxib
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