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How are peptides loaded onto MHC II?
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, 1. Antigen is taken up from the extracellular space into intracellular vesicles
2. In early endosomes of neutral pH, endosomal proteases are inactive
3. Acidification of vesicles activates proteases to degraded antigen into
peptide fragments
4. Vesicles containing peptides fuse with vesicles containing MHC class II
molecules
How many loci are genes for MHC and associated proteins located in?
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Genes for MHC and associated proteins are located in a single locus.
Exogenous pathway
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- Helper
- Phagocytosis, phagosome, ER
- MHC class II
- CD4+, T cell
Since each individual's __________ of MHC is __________, each individual has a _________ __________
of TCRs.
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How are peptides loaded onto MHC II?
Give this one a go later!
, 1. Antigen is taken up from the extracellular space into intracellular vesicles
2. In early endosomes of neutral pH, endosomal proteases are inactive
3. Acidification of vesicles activates proteases to degraded antigen into
peptide fragments
4. Vesicles containing peptides fuse with vesicles containing MHC class II
molecules
How many loci are genes for MHC and associated proteins located in?
Give this one a go later!
Genes for MHC and associated proteins are located in a single locus.
Exogenous pathway
Give this one a go later!
- Helper
- Phagocytosis, phagosome, ER
- MHC class II
- CD4+, T cell
Since each individual's __________ of MHC is __________, each individual has a _________ __________
of TCRs.
Give this one a go later!
