ONS/ONCC Chemotherapy
Immunotherapy Certificate
Questions and Answers (100% Pass)
Lesson 1: Foundations to Set the Stage
The Normal Cell Cycle
→ -The cell cycle refers to the ordered seres of processes of DNA
replication and mitosis, or cell division
-Cell nucleus regulates these processes by gathering and processing
complexes molecular information
Interphase and Mitotic Phase
→ Cell division produces two identical cells through these two
major phases
During interphase:
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→ Cell grows and DNA is replicated through the following three
steps:
1: First growth phase (G1 or first gap)
2: Synthesis phase (S phase)
3:Mitotic Phse (M phase)
First Growth Phase (G1 or first gap)
→ -cells increase in size
-reproduce RNA
-"quality assurance" test that the cell will be ready to synthesis DNA
-Length of time is variable, can be from hours to days
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Synthesis Phase (S phase)
→ -DNA replicates
-Results in the formation of identical pairs of DNA (chromatids)
-which are attached a t the centromere
-lasts 2-10 hours
Mitotic Phase (M phase)
→ -Replicated chromosomes are aligned, separated, and move
into 2 new, identical daughter cells
-takes about 30-60 minutes
Major points of cell regulation are entry and exit from
→ -G1 checkpoint
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-S Phase
-G2 checkpoint
-M phase
Restriction Point
→ -The transition from the resting phase into an actively dividing
phase (G0-G1) is a point where cellular transformation can
occur
-During this time, cells pass through a transition phase known as a restriction
point
-Extracellular growth factors trigger reentry into G1, and GF are required to
send the cells past the restriction point, or the point of no return
G0 Phase (resting phase)
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