(Correct & Accurate)
Overview of Clindamycin Right Ans - -Time dependent killing
-Bacteriostatic
-PO/Parental
-Rapid/complete absorption
MOA of clindamycin Right Ans - inhibits protein synthesis
ADE of clindamycin Right Ans - -skin rash
-neutropenia
-hepatic dysfunction
*-C. DIFF*
Clindamycin indications Right Ans - -Gram+
-Backup for CAP
-Endocarditis in valve pts
-anaerobes
Linezolid (Zyvox) Right Ans - -Oxazolidinone
-PO/Parenteral
-Time dependent killing
-bacteriostatic
MOA: inhibits protein synthesis and prevents formation of ribosome complex
Linezolid pharmacokinetics Right Ans - -oral (bioavailability almost 100%)
and IV
-30% CSF penetration
ADE of linezolid Right Ans - -thrombocytopenia (inc risk >2 wks tx)
-anemia/neutropenia
-optic & peripheral neuropathy
-lactic acidosis
*-Serotonin syndrome w/ SSRIs*
Linezolid indications Right Ans - -VRE
-HCAP/CAP