PHM 350 EXAM 1 Questions And Verified Detailed
Answers Latest Update
If the volume of distribution of a drug is calculated to be the same as plasma volume,
then one should conclude that:
A. The drug has been eliminated before plasma drug concentration was measured.
B. The drug did not leave the systemic circulation.
C. The drug is present in the blood and the extracellular extravascular space but is
absent from the intracellular space.
D. The drug is sequestered to cells of a single organ or to a specific organelle within
cells.
E. None of the above - Answer B
The Therapeutic Range of a drug:
A. Is the range of plasma concentration of the drug in which the drug produces the
desired therapeutic without producing any toxic effects or adverse side effects also
produced.
B. Can only be determined for antagonist drugs.
C. Can only be determined for agonist drugs.
D. Is the range of plasma concentration of the drug in which the drug produces the
desired therapeutic effect regardless of any toxic effects or adverse side effects also
produced - Answer A
The bioavailability of a drug administered orally (and swallowed!!!) is 0.9. Given this
information, you conclude that for an orally administered dose of this drug:
A. This drug is rapidly eliminated.
B. This drug is slowly eliminated.
C. Most of an orally administered dose of this drug is absorbed into the blood.
D. This drug will likely have insignificant therapeutic benefits if those benefits require
,the drug to enter the systemic - Answer C
The Kd for a drug is:
A. Defined as the concentration of drug necessary to product 50% of the maximum
response when receptors are activated
B. Defined as the concentration of drug at which 50% of the receptors in a given
population will each be bound by a molecule of the drug (with the remaining receptors
being unoccupied by drug)
C. Defined as the concentration of drug required to inhibit an agonist response by 50%
assuming sufficient agonist s present to produce a response that is 100% of the
maximum response
D. Defined as the concentration of drug necessary to inhibit agonist binding by 50%
assuming sufficient agonist is present to bind to 100% of the receptors - Answer B
You are given the same oral dose of a drug every 24 hours. By the sixth day, the drug
seems to have a reduced effectiveness (compared to its effect on the first couple of
days). This reduced effectiveness could be the result of:
A. Increased rate of delivery of the drug from the plasma to its sites of action and
increased affinity of the drug for the receptors through which the response is induced.
B. Increased affinity of the drug for the receptors through which the response is
induced.
C. Increased rate of delivery of the drug from the plasma to its sites of action.
D. Decreased absorption of drug from the gastrointestinal tract.
E. Decreased rate of elimination - Answer D
The liver enzyme Enzyme Z metabolizes Drug A. If Drug A is administered repeatedly,
then the amount of Enzyme Z in the liver is increased. Consequently....
A. The rate of metabolism of Drug A will not change.
B. The rate of metabolism of any drug metabolized by Enzyme Z is decreased.
C. The half-life of all drugs metabolized by Enzyme Z will be decreased
D. The half-life of Drug A will be increased.
, E. The half-life of Drug B, also metabolized by Enzyme Z, will not be affected - Answer C
When a drug is dissolved in an aqueous (water-based) solution, the concentration of
ionized form of the drug is dependent on:
A. The acidity (pH) of the aqueous solution.
B. The lipid solubility of the drug.
C. The pKa of the drug.
D. The amount of drug dissolved in the solution.
E. The acidity (pH) of the aqueous solution, and the pKa of the drug, and the amount of
the drug dissolved in the solution - Answer E
Drug A is administered repeatedly with a constant interval between consecutive doses
and with a constant dose. The mean plasma concentration of Drug A is measured. The
concentration:
A. Is independent on the route of administration but is dependent on the dose and the
interval between consecutive doses.
B. Is independent of the clearance volume for the drug.
C. Is independent of the route of administration
D. Is independent of the dose of drug administered but not of the interval between
consecutive doses
E. Is dependent on the dose and the interval between consecutive doses - Answer E
The therapeutic threshold concentration (aka minimal effective concentration) of a
drug:
A. Determines the pharmacological and clinical (or physiological) efficacies of the drug.
B. Is affected by the ability of the body to eliminate (metabolize and/or excrete) the drug
and depends on the rate of absorption of the drug.
C. Depends on the rate of absorption of the drug.
D. Is affected by the ability of the body to eliminate (metabolize and/or excrete) the drug.
E. Is the minimum plasma concentration of the drug which is required to induce the
desired therapeutic response - Answer E
Answers Latest Update
If the volume of distribution of a drug is calculated to be the same as plasma volume,
then one should conclude that:
A. The drug has been eliminated before plasma drug concentration was measured.
B. The drug did not leave the systemic circulation.
C. The drug is present in the blood and the extracellular extravascular space but is
absent from the intracellular space.
D. The drug is sequestered to cells of a single organ or to a specific organelle within
cells.
E. None of the above - Answer B
The Therapeutic Range of a drug:
A. Is the range of plasma concentration of the drug in which the drug produces the
desired therapeutic without producing any toxic effects or adverse side effects also
produced.
B. Can only be determined for antagonist drugs.
C. Can only be determined for agonist drugs.
D. Is the range of plasma concentration of the drug in which the drug produces the
desired therapeutic effect regardless of any toxic effects or adverse side effects also
produced - Answer A
The bioavailability of a drug administered orally (and swallowed!!!) is 0.9. Given this
information, you conclude that for an orally administered dose of this drug:
A. This drug is rapidly eliminated.
B. This drug is slowly eliminated.
C. Most of an orally administered dose of this drug is absorbed into the blood.
D. This drug will likely have insignificant therapeutic benefits if those benefits require
,the drug to enter the systemic - Answer C
The Kd for a drug is:
A. Defined as the concentration of drug necessary to product 50% of the maximum
response when receptors are activated
B. Defined as the concentration of drug at which 50% of the receptors in a given
population will each be bound by a molecule of the drug (with the remaining receptors
being unoccupied by drug)
C. Defined as the concentration of drug required to inhibit an agonist response by 50%
assuming sufficient agonist s present to produce a response that is 100% of the
maximum response
D. Defined as the concentration of drug necessary to inhibit agonist binding by 50%
assuming sufficient agonist is present to bind to 100% of the receptors - Answer B
You are given the same oral dose of a drug every 24 hours. By the sixth day, the drug
seems to have a reduced effectiveness (compared to its effect on the first couple of
days). This reduced effectiveness could be the result of:
A. Increased rate of delivery of the drug from the plasma to its sites of action and
increased affinity of the drug for the receptors through which the response is induced.
B. Increased affinity of the drug for the receptors through which the response is
induced.
C. Increased rate of delivery of the drug from the plasma to its sites of action.
D. Decreased absorption of drug from the gastrointestinal tract.
E. Decreased rate of elimination - Answer D
The liver enzyme Enzyme Z metabolizes Drug A. If Drug A is administered repeatedly,
then the amount of Enzyme Z in the liver is increased. Consequently....
A. The rate of metabolism of Drug A will not change.
B. The rate of metabolism of any drug metabolized by Enzyme Z is decreased.
C. The half-life of all drugs metabolized by Enzyme Z will be decreased
D. The half-life of Drug A will be increased.
, E. The half-life of Drug B, also metabolized by Enzyme Z, will not be affected - Answer C
When a drug is dissolved in an aqueous (water-based) solution, the concentration of
ionized form of the drug is dependent on:
A. The acidity (pH) of the aqueous solution.
B. The lipid solubility of the drug.
C. The pKa of the drug.
D. The amount of drug dissolved in the solution.
E. The acidity (pH) of the aqueous solution, and the pKa of the drug, and the amount of
the drug dissolved in the solution - Answer E
Drug A is administered repeatedly with a constant interval between consecutive doses
and with a constant dose. The mean plasma concentration of Drug A is measured. The
concentration:
A. Is independent on the route of administration but is dependent on the dose and the
interval between consecutive doses.
B. Is independent of the clearance volume for the drug.
C. Is independent of the route of administration
D. Is independent of the dose of drug administered but not of the interval between
consecutive doses
E. Is dependent on the dose and the interval between consecutive doses - Answer E
The therapeutic threshold concentration (aka minimal effective concentration) of a
drug:
A. Determines the pharmacological and clinical (or physiological) efficacies of the drug.
B. Is affected by the ability of the body to eliminate (metabolize and/or excrete) the drug
and depends on the rate of absorption of the drug.
C. Depends on the rate of absorption of the drug.
D. Is affected by the ability of the body to eliminate (metabolize and/or excrete) the drug.
E. Is the minimum plasma concentration of the drug which is required to induce the
desired therapeutic response - Answer E
