BIOS 390- Unit 3 Receptors Exam with Complete
Solutions
What is the F domain involved in? Correct Ans-- ligand specificity
- has AF-2 domain thus transactivation
Nuclear receptors commonly work as what? Correct Ans-dimers
Activation of the receptor does or does not equal activation of transcription? Correct Ans-
does not
What is the first step in nuclear receptors? Correct Ans-hormone entering the cell
Once in the cell the patterns of interaction with receptors and translocation to the nucleus
differs for what 3 hormone types? Correct Ans-1. glucocorticoids
2. gonadal steroids
3. thyroid hormones and vitamins
How do glucocorticoids interact with the nuclear receptor in the cell ? Correct Ans-- bind
to receptor as monomers in the cytoplasm
, BIOS 390- Unit 3 Receptors Exam with Complete
Solutions
- dimerize in cytoplasm
- then transported as dimer to nucleus
How do gonadal steroids interact with the nuclear receptor in the cell ? Correct Ans-- bind
to receptor as monomer in cytoplasm
- monomer entres nucleus
- dimerize in nucleus
How do thyroid hormones interact with the nuclear receptor in the cell ? Correct Ans-- the
receptors are bound to DNA as a dimer in the absence of the ligand
- ligand (thyroid hormone) binds to the dimer already bound to DNA
nuclear receptors have what signal to allow them to move in and out of the nucleus to varying
degrees? Correct Ans-nuclear localization signal (NLS)
Where do steroid and glucocorticoid receptors reside until they bind to a hormone? What are
they associated with in the absence of a ligand? Correct Ans-cytoplasm; heat shock protein
, BIOS 390- Unit 3 Receptors Exam with Complete
Solutions
The binding of a steroid or glucocorticoid hormone to their receptor results in what?
Correct Ans-receptor conformational change, release of heat shock protein complex, which
exposes NLS and receptor dimerization domains
What are the 2 requirements for hormone responsiveness? Correct Ans-hormone is
available and there are receptors
What is the first order receptor? Correct Ans-the receptor that the hormone binds to
What are the two ways hormones can be secreted with regard to synthesis? Correct Ans--
independent of synthesis
- directly coupled to synthesis
What does it mean if you upregulate the synthesis of a hormone and see no change in
secretion? Correct Ans-secretion is independent of synthesis
Which type of hormones is stored in the cells in large quantities? Correct Ans-peptide and
protein hormones
Solutions
What is the F domain involved in? Correct Ans-- ligand specificity
- has AF-2 domain thus transactivation
Nuclear receptors commonly work as what? Correct Ans-dimers
Activation of the receptor does or does not equal activation of transcription? Correct Ans-
does not
What is the first step in nuclear receptors? Correct Ans-hormone entering the cell
Once in the cell the patterns of interaction with receptors and translocation to the nucleus
differs for what 3 hormone types? Correct Ans-1. glucocorticoids
2. gonadal steroids
3. thyroid hormones and vitamins
How do glucocorticoids interact with the nuclear receptor in the cell ? Correct Ans-- bind
to receptor as monomers in the cytoplasm
, BIOS 390- Unit 3 Receptors Exam with Complete
Solutions
- dimerize in cytoplasm
- then transported as dimer to nucleus
How do gonadal steroids interact with the nuclear receptor in the cell ? Correct Ans-- bind
to receptor as monomer in cytoplasm
- monomer entres nucleus
- dimerize in nucleus
How do thyroid hormones interact with the nuclear receptor in the cell ? Correct Ans-- the
receptors are bound to DNA as a dimer in the absence of the ligand
- ligand (thyroid hormone) binds to the dimer already bound to DNA
nuclear receptors have what signal to allow them to move in and out of the nucleus to varying
degrees? Correct Ans-nuclear localization signal (NLS)
Where do steroid and glucocorticoid receptors reside until they bind to a hormone? What are
they associated with in the absence of a ligand? Correct Ans-cytoplasm; heat shock protein
, BIOS 390- Unit 3 Receptors Exam with Complete
Solutions
The binding of a steroid or glucocorticoid hormone to their receptor results in what?
Correct Ans-receptor conformational change, release of heat shock protein complex, which
exposes NLS and receptor dimerization domains
What are the 2 requirements for hormone responsiveness? Correct Ans-hormone is
available and there are receptors
What is the first order receptor? Correct Ans-the receptor that the hormone binds to
What are the two ways hormones can be secreted with regard to synthesis? Correct Ans--
independent of synthesis
- directly coupled to synthesis
What does it mean if you upregulate the synthesis of a hormone and see no change in
secretion? Correct Ans-secretion is independent of synthesis
Which type of hormones is stored in the cells in large quantities? Correct Ans-peptide and
protein hormones
