Neuropharmacology - Advanced
Pharm - NURS8024 - Exam Three
Questions and Answers 100%
Verified
In Parkinson's disease the amount of __________ lost directly correlates to severity of
symptoms. - ANSWER - Dopamine
The goal of treatment for Parkinson's disease is to CURE and REVERSE
degeneration. T / F - ANSWER - False - Tx focus is on restoring balance
Sinamet (Levodopa & Carbidopa) MOA includes: - ANSWER - Assist in conversion of
levodopa to dopamine in the basal nigra - Increase in body's production of
dopamine
How does Carbidopa help in Parkinson's disease? - ANSWER - Carbidopa enhances
availability of levodopa to cross the BBB. Decrease metabolism of levodopa in the GI
system
An NP understand that treatment effectiveness _____________ between the 3rd and
5th year of Parkinson treatment using sinemet. - ANSWER - Decreases
Important Pt Ed on Levodopa: - ANSWER - Take on an Empty Stomach
ADE with Levodopa include: - ANSWER - CNS effects (Visual/Auditory Hallucinations,
AIM, depression, GI effects, Tachy, Acute glaucoma
Amantadine is used to treat? - ANSWER - MINOR Parkinsons
MOA for Amantadine includes: - ANSWER - Enhances dopaminergic
neurotransmission, muscarininc blocking
, An NP would be cautious in prescribing Amantadine for minor Parkinson's in a
patient with what dx? - ANSWER - Seizure D/O & CHF
Name two dopamine receptor agonists: - ANSWER - Ropinirole & Pramipexole
Name the one anticholingeric for EPS / Parkinsons - ANSWER - Cogentin /
Benzotropine
ADE of dopamine receptor agonists include: - ANSWER - GI, Postural HYPO,
Dyskinesias, confusion, delusions, hallucinations, IMPULSIVITY
Ropinirole and Pramipexole CAUSE: - ANSWER - IMPULSIVITY
Cogentin / Benzotropine is an________________ drug - ANSWER - Anticholinergic
MAO-B Inbhitors - ANSWER - Monamine Oxidase B Inhibitors
When prescribing MAO-B Inhibitors use CAUTION with what two medications? -
ANSWER - Fluoxetine or Meperidine (Prozac or Demerol)
MAO-B Inhibitors include: - ANSWER - Selegiline (Eldepryl) & Rasagiline (Azilect)
Use MAO-B Inhibitors _____________ and adjunct with __________. - ANSWER - Early ;
Levodopa
COMT (Catehcol-O-Methyltransferase Inhibitors) - ANSWER - Help with uptake of
Levodopa which increases dopamine in CNS
CAUTION when using _______________ & ___________ as both are major enzymes that
metabolize catecholamines. - ANSWER - MAO-B and COMT
Pharm - NURS8024 - Exam Three
Questions and Answers 100%
Verified
In Parkinson's disease the amount of __________ lost directly correlates to severity of
symptoms. - ANSWER - Dopamine
The goal of treatment for Parkinson's disease is to CURE and REVERSE
degeneration. T / F - ANSWER - False - Tx focus is on restoring balance
Sinamet (Levodopa & Carbidopa) MOA includes: - ANSWER - Assist in conversion of
levodopa to dopamine in the basal nigra - Increase in body's production of
dopamine
How does Carbidopa help in Parkinson's disease? - ANSWER - Carbidopa enhances
availability of levodopa to cross the BBB. Decrease metabolism of levodopa in the GI
system
An NP understand that treatment effectiveness _____________ between the 3rd and
5th year of Parkinson treatment using sinemet. - ANSWER - Decreases
Important Pt Ed on Levodopa: - ANSWER - Take on an Empty Stomach
ADE with Levodopa include: - ANSWER - CNS effects (Visual/Auditory Hallucinations,
AIM, depression, GI effects, Tachy, Acute glaucoma
Amantadine is used to treat? - ANSWER - MINOR Parkinsons
MOA for Amantadine includes: - ANSWER - Enhances dopaminergic
neurotransmission, muscarininc blocking
, An NP would be cautious in prescribing Amantadine for minor Parkinson's in a
patient with what dx? - ANSWER - Seizure D/O & CHF
Name two dopamine receptor agonists: - ANSWER - Ropinirole & Pramipexole
Name the one anticholingeric for EPS / Parkinsons - ANSWER - Cogentin /
Benzotropine
ADE of dopamine receptor agonists include: - ANSWER - GI, Postural HYPO,
Dyskinesias, confusion, delusions, hallucinations, IMPULSIVITY
Ropinirole and Pramipexole CAUSE: - ANSWER - IMPULSIVITY
Cogentin / Benzotropine is an________________ drug - ANSWER - Anticholinergic
MAO-B Inbhitors - ANSWER - Monamine Oxidase B Inhibitors
When prescribing MAO-B Inhibitors use CAUTION with what two medications? -
ANSWER - Fluoxetine or Meperidine (Prozac or Demerol)
MAO-B Inhibitors include: - ANSWER - Selegiline (Eldepryl) & Rasagiline (Azilect)
Use MAO-B Inhibitors _____________ and adjunct with __________. - ANSWER - Early ;
Levodopa
COMT (Catehcol-O-Methyltransferase Inhibitors) - ANSWER - Help with uptake of
Levodopa which increases dopamine in CNS
CAUTION when using _______________ & ___________ as both are major enzymes that
metabolize catecholamines. - ANSWER - MAO-B and COMT
