COMSAE ALL QUESTIONS WITH
COMPLETE SOLUTIONS
1st generation antihistamines Correct Answers
diphenhydramine, dimenhydrinate, chlorpheniramine "en/ine" or
"en/ate"
use: allergy motion sick, sleep aid
AE: sedation, antimuscarinic, anti alpha adrenergic
2 bitemporal hemianopia Correct Answers optic chiasm,
pituitary tumor
2nd generation antihistimes Correct Answers loratadine,
fexofenadine, desloratadine, cetgirizine "adines"
use: allergy; far less sedation than first gen bc dec entry into
CNS
A beta lipoproteinemia Correct Answers AR
chylomicrons VLDL LDL absent
deficiency in the B's ApoB-48, and B100
infants: severe fat malabsorption, steatorrhea, fail to thrive
later: retinitis pigments, spinocerebellar degeneration> Vit E
deficiency, progressive ataxia, acanthocytosis
Tx: large dose oral Vitamin E; restriction of long chain fatty
acids
Acanthocytosis Correct Answers spiky spiny RBC
,-indicative of pancreatitis, cirrhosis or abetalipoproteinemia
Acetaminophen Correct Answers moa: reversibly inhibit COX,
mostly CNS;
AE: OD>> hepatic necrosis; NAPQI depletes glutathione>>
toxic byproducts liver; NAC= antidote>> regenerate glutathione
Acidic amino acids Correct Answers aspartic acid
glutamic acid
neg charged @ body pH
Albinism Correct Answers Defective tyrosinase (DEC DOPA>
MELANIN)
ALKAPTONURIA Correct Answers Congenital AR
deficiency homogentisate oxidase (tyrosine> fumarate);
pigment forming homogentisic acid accumulate in tissue;
findings: bluish black CT; ear cartilage, sclerae (ochronosis);
urine black on prolong exposure to air; poss debilitating
arthralgia (toxic to cartilage)
Alkaptonuria Correct Answers homogentisate oxidase
deficiency (tyrosine> homogentisic acid>*** maleylacetoacetic
acid> fumarate> TCA
alpha agonists should be avoided in Correct Answers closed
angle glaucoma pts
Alpha galactosidase A (fAbrAy disease) Correct Answers
Fabr(a)y disease
,Early: triad: peripheral neuropathy, angiokeratomas,
hypohidrosis
LatE: progressive renal fail, CV disease
buildup: Ceramide trihexoside; X link Recessive
think Quinn Fabray gives to her kids (x link)
Amino Acids only L in proteins; glucogenic Correct Answers I
met his valentine, she's so sweet (glycogenic)
methionine
histidine
valine
=gluconeogenic
AntiHistamines Correct Answers Reversible inhibitor of H1
histamine receptors
Apo A-I Correct Answers Activates LCAT (maturation of
HDL)
chylomicron and HDL
Apo B-48 Correct Answers mediate chylomicron secrete to
lymphatics
specific to chylomicron and remnant!!
Apo C-II Correct Answers lipoprotien lipase Cofactor that
Catalyzes Cleavage
Chylomicron; VLDL, HDL
, Apo E Correct Answers mediate remnant uptake (Everything
Except LDL)
Arginine Correct Answers -creatine
-urea
(BH4)>nitric oxid
Arylsulfatase A=Metaryl chromatic leukodystrophy Correct
Answers Metachromatic leukodystrophy
central and peripheral demyelination, w/ ataxia, dementia
AR
buildup Cerebroside sulfate
Axillary nerve C5-C6 Correct Answers flat deltoid; loss arm
abduction, loss sensation over deltoid and lateral arm
B-100 Correct Answers bind LDL receptor
needed on all the density DL's except High (HDL)
VLDL, IDL, LDL
Baroreceptors Correct Answers hypotension: dec arterial
pressure, dec stretch, dec afferent receptor firing, increase
efferent sympathetic firing, dec efferent parasympathetic
stimulation>> vasoconstriction> inc HR/contractility/BP
response to severe hemorrhage
COMPLETE SOLUTIONS
1st generation antihistamines Correct Answers
diphenhydramine, dimenhydrinate, chlorpheniramine "en/ine" or
"en/ate"
use: allergy motion sick, sleep aid
AE: sedation, antimuscarinic, anti alpha adrenergic
2 bitemporal hemianopia Correct Answers optic chiasm,
pituitary tumor
2nd generation antihistimes Correct Answers loratadine,
fexofenadine, desloratadine, cetgirizine "adines"
use: allergy; far less sedation than first gen bc dec entry into
CNS
A beta lipoproteinemia Correct Answers AR
chylomicrons VLDL LDL absent
deficiency in the B's ApoB-48, and B100
infants: severe fat malabsorption, steatorrhea, fail to thrive
later: retinitis pigments, spinocerebellar degeneration> Vit E
deficiency, progressive ataxia, acanthocytosis
Tx: large dose oral Vitamin E; restriction of long chain fatty
acids
Acanthocytosis Correct Answers spiky spiny RBC
,-indicative of pancreatitis, cirrhosis or abetalipoproteinemia
Acetaminophen Correct Answers moa: reversibly inhibit COX,
mostly CNS;
AE: OD>> hepatic necrosis; NAPQI depletes glutathione>>
toxic byproducts liver; NAC= antidote>> regenerate glutathione
Acidic amino acids Correct Answers aspartic acid
glutamic acid
neg charged @ body pH
Albinism Correct Answers Defective tyrosinase (DEC DOPA>
MELANIN)
ALKAPTONURIA Correct Answers Congenital AR
deficiency homogentisate oxidase (tyrosine> fumarate);
pigment forming homogentisic acid accumulate in tissue;
findings: bluish black CT; ear cartilage, sclerae (ochronosis);
urine black on prolong exposure to air; poss debilitating
arthralgia (toxic to cartilage)
Alkaptonuria Correct Answers homogentisate oxidase
deficiency (tyrosine> homogentisic acid>*** maleylacetoacetic
acid> fumarate> TCA
alpha agonists should be avoided in Correct Answers closed
angle glaucoma pts
Alpha galactosidase A (fAbrAy disease) Correct Answers
Fabr(a)y disease
,Early: triad: peripheral neuropathy, angiokeratomas,
hypohidrosis
LatE: progressive renal fail, CV disease
buildup: Ceramide trihexoside; X link Recessive
think Quinn Fabray gives to her kids (x link)
Amino Acids only L in proteins; glucogenic Correct Answers I
met his valentine, she's so sweet (glycogenic)
methionine
histidine
valine
=gluconeogenic
AntiHistamines Correct Answers Reversible inhibitor of H1
histamine receptors
Apo A-I Correct Answers Activates LCAT (maturation of
HDL)
chylomicron and HDL
Apo B-48 Correct Answers mediate chylomicron secrete to
lymphatics
specific to chylomicron and remnant!!
Apo C-II Correct Answers lipoprotien lipase Cofactor that
Catalyzes Cleavage
Chylomicron; VLDL, HDL
, Apo E Correct Answers mediate remnant uptake (Everything
Except LDL)
Arginine Correct Answers -creatine
-urea
(BH4)>nitric oxid
Arylsulfatase A=Metaryl chromatic leukodystrophy Correct
Answers Metachromatic leukodystrophy
central and peripheral demyelination, w/ ataxia, dementia
AR
buildup Cerebroside sulfate
Axillary nerve C5-C6 Correct Answers flat deltoid; loss arm
abduction, loss sensation over deltoid and lateral arm
B-100 Correct Answers bind LDL receptor
needed on all the density DL's except High (HDL)
VLDL, IDL, LDL
Baroreceptors Correct Answers hypotension: dec arterial
pressure, dec stretch, dec afferent receptor firing, increase
efferent sympathetic firing, dec efferent parasympathetic
stimulation>> vasoconstriction> inc HR/contractility/BP
response to severe hemorrhage
