13TH EDITION, JAMES W. KALAT.
What are the 2 immune responses? (__immunity) - ANSWER innate immunity
acquired immunity
which immunity is non specific? which is specific and adaptive? (acquired or innate) -
ANSWER 1. non specific -> innate immunity
2. specific -> acquired immunity
What's an inflammatory response? - ANSWER response to infection or tissue injury
which immunity has barriers against general pathogens? - ANSWER innate
immunity
What are the steps to an inflammatory response? - ANSWER Chemicals are
released from injured or infected site
Blood vessels dilate and allows neutrophils to pass into tissue
Phagocytosis by neutrophils; causes pH change
Monocytes migrate into tissues; now macrophages and cont phagocytosis
what are some signs of inflammation? - ANSWER redness, swelling, heat, pain,
loss of function
NK cells are part of what cell class? - ANSWER class of lymphocytes
where are NK cells found? - ANSWER blood and peripheral lymph organs
Nk cells recognize and kill what cells? - ANSWER kill host cells that are coated with
IgG
how do NK cells activate phagocytes? - ANSWER through the use of interferon
what are interferons? - ANSWER soluble proteins secreted by cells
Interferon is a cytokine and mainly the big reason it is used is to do what?** -
ANSWER prevent viral replication
what else does interferon do? - ANSWER Elicit other cellular reactions
Influence NK cells
Also active in adaptive system as well as innate system
what is complement? - ANSWER collective group of proteins found in blood
True or False
, complement acts in both innate immunity and adaptive immunity systems\\? -
ANSWER TRUE
Activation of complement causes what to occur? - ANSWER activated cause
complement cascade (3 pathways)
Classical is a type of complement pathway in which what happens? - ANSWER
Classical: adaptive, activated C1 binds to antigen-antibody complexes that are
formed in the body
Innate is a type of complement pathway in which what happens? - ANSWER
Innate; microbial surfaces and plasma lectin binding
(big idea: it binds to microbial surfaces)
Complement has many physiological effects. Name 2 - ANSWER Opsonization of
microbes..makes them more easy to find and more readily recognized and more
easily destroyed
Promotion of phagocytosis
Stimulate inflammation..stim. continued inflammatory response
Stimulate cell lysis
Membrane attack complex
what are the 2 components of acquired immunity? - ANSWER humoral (B cells)
cell mediated (t cells)
if the pathogen gets passed innate immunity what does your body also have? (what
other immunity system) - ANSWER adaptive immunity
adaptive immunity responds specifically to what? - ANSWER to antigens
what is the goal of adaptive immunity? - ANSWER to neutralize, detoxify, and
eliminate
what is the main cell type of adaptive immunity? - ANSWER lymphocytes
in the adaptive immunity, macrophages are responsible for what? - ANSWER for
process and presentation of antigens (antigen presenting cells)
adaptive immunity develops where? matures where? - ANSWER Develop in yolk
sac, then fetal liver, then bone marrow (once patient is born)
Mature in either bone marrow (B cells) or thymus (T cells)..
in humoral immunity, ___ are secreted by the B cells into ___ - ANSWER
Antibodies (Ig molecules) are secreted by B cells
Secreted into body's fluids ..(aka hemour)
how many stages of maturation are there in humoral immunity? what are they? -
ANSWER 3 stages of maturation
Lymphoblast
Prolymphocyte