APHA NAPLEX REVIEW QUESTIONS AND ANSWERS WITH SOLUTIONS 2024

APHA NAPLEX REVIEW QUESTIONS
AND ANSWERS WITH SOLUTIONS 2024
IfOtheOpkaOofOaOweakOacidOisO2.5,OatOwhichOpHOwillOthisOdrugObecomeOmoreOionized?



A.OpHO5

B.OpHO2.5

C.OpHO1.5

D.OpHO1O-OANSWEROA.OForOaOweakOacid,OaOhigherOpHOincreasesOionization



WhichOequationOdescribesOtheOrateOofOdrugOdissolutionOfromOaOtablet?



A.OFick'sOLaw

B.OHenderson-HasselbalchOequation

C.OMichaelis-MentenOequation

D.ONoyes-WhitneyOequationO-OANSWEROD.OTheONoyes-
WhitneyOequationOdescribesOtheOrateOofOdrugOdissolutionOfromOaOtablet.OFick'sOfirstOlawOofOdiffusionOisOsi
milarOtoOtheONoyes-
WhitneyOequationOinOthatObothOequationsOdescribeOdrugOmovementOattributableOtoOaOconcentrationOgra
dient.OTheOMichealis-MentenOequationOinvolvesOenzymeOkinetics,OwhereasOHenderson-
HasselbalchOequationsOareOusedOforOdeterminationOofOpHOofOtheObufferOandOtheOextentOofOionizationOofOa
OdrugOmolecule




TheOpHOofOaObufferOsystemOcanObeOcalculatedOwith



A.OtheOHenderson-HasselbalchOequation

B.OtheONoyes-WhitneyOequation

C.OtheOMichealis-MentionOequation

D.OYong'sOequationO-OANSWEROA.OTheOHenderson-
HasselbalchOequationOformOaOweakOacidOandOitsOsaltOisOrepresentedOasOpHO=OpkaO+OlogO([salt]/[acid]),Owhe
reOpkaOisOtheOnegativeOlogOofOtheOdissolutionOconstantOofOaOweakOacid,OasO[salt]/[acid]OisOtheOratioOofOtheO
molarOconcentrationOofOsaltOandOacidOusedOtoOprepareOaObuffer

,IfOtheOpkaOofOaOdrugOisO5,OatOwhichOofOtheOfollowingOpHOvaluesOdoOtheOionicOandOnonionicOformsOofOtheOdr
ugOexistOatOequalOratio?



A.OpHO1

B.OpHO5

C.OpHO7

D.OpHO9O-OANSWEROB.OWhenOtheOpHO=Opka,OtheOratioOofOionizedOtoOun-ionizedObecomesOtheOsame



WhatOisObioavailability?



A.OBioavailabilityOisOtheOmeasurementOofOtheOrateOandOextentOofOactiveOdrugOthatOreachesOtheOsystemicOc
irculation

B.OItOisOtheOrelationshipObetweenOtheOphysicalOandOchemicalOpropertiesOofOaOdrugOandOitsOsystemicOabsor
ption

C.OItOisOtheOmovementOofOtheOdrugOintoObodyOtissuesOoverOtime

D.OItOisOtheOdissolutionOofOtheOdrugOinOtheOGIOtractO-
OANSWEROA.OBioavailabilityOisOtheOmeasurementOofOtheOrateOandOextentOofOsystemicOcirculationOofOanOact

iveOdrug



WhichOofOtheOfollowingOmayObeOusedOtoOassessOtheOrelativeObioavailabilityOofOtwoOchemicallyOequivalentO
drugOproductsOinOaOcrossoverOstudy?



A.ODissolutionOtest

B.OPeakOconcentration

C.OTime-to-peakOconcentration

D.OAreaOunderOtheOplasma-levelOtimeOcurveO-
OANSWEROD.OTheOplasmaOdrugOconcentrationOversusOtimeOcurveOmeasuresOtheObioavailabilityOofOaOdrugOf

romOaOproduct.OTheOpeakOplasmaOdrugOconcentrationO(Cmax)OrelatesOtoOtheOintensityOofOtheOpharmacolo
gicOresponse,OwhileOtheOtimeOforOpeakOplasmaOdrugOconcentrationO(Tmax)OrelatesOtoOtheOrateOofOsystemic
Oabsorption

,WhatOconditionOusuallyOincreasesOtheOrateOofOdrugOdissolutionOforOaOtablet?



A.OIncreaseOtheOparticleOsizeOofOtheOdrug

B.ODecreaseOtheOsurfaceOareaOofOtheOdrug

C.OUseOofOionized,OorOsalt,OformOofOtheOdrug

D.OUseOofOtheOfreeOacidOorOfreeObaseOformOofOtheOdrugO-
OANSWEROC.OTheOionized,OorOsalt,OformOofOaOdrugOisOgenerallyOmoreOwaterOsolubleOandOthereforeOdissolve

sOmoreOrapidlyOthanOtheOnonionizedO(freeOacidOorOfreeObase)OformOofOtheOdrug.OAccordingOtoOtheONoyes-
WhitneyOequation,OtheOdissolutionOrateOisOdirectlyOproportionOtoOtheOsurfaceOareaOandOinverselyOproporti
onalOtoOtheOparticleOsize.OTherefore,OanOincreaseOinOtheOparticleOsizeOorOaOdecreaseOinOtheOsurfaceOareaOsl
owsOtheOdissolutionOrate



IfOtheOpkaOofOaOweakObaseOdrugOisO8.3,OatOwhichOofOtheOfollowingOpHOvaluesOdoesOthisOdrugObecomeOmor
eOionized?



A.OpHO4

B.OpHO9

C.OpHO10

D.OpHO13O-OANSWEROA.OForOaOweakObase,OaOlowerOpHOvalueOincreaseOionizationOofOtheOmolecule



WhichOofOtheOfollowingOdosageOformsOmayOuseOsurface-activeOagentsOinOtheirOformulations?



A.OEmulsions

B.OSuspensions

C.OColloidalOdosageOforms

D.OCreams

E.OAllOofOtheOAboveO-
OANSWEROE.OSurfaceOactiveOagentsOfacilitateOemulsionOformationObyOloweringOtheOinterfacialOtensionObet

weenOtheOoilOandOwaterOphases.OAdsorptionOofOsurfactantsOonOinsolubleOparticlesOenablesOtheseOparticle
sOtoObeOdispersedOinOtheOformOofOaOsuspension



WhichOofOtheOfollowingOstatementsOaboutOlyophilicOcolloidalOdispersionsOisOtrue?

, A.OTheyOtendOtoObeOmoreOsensitiveOtoOtheOadditionOofOelectrolytesOthanOdoOlyophobicOsystems

B.OTheyOtendOtoObeOmoreOviscousOthanOlyophobicOsystems

C.OTheyOcanObeOprecipitatedObyOprolongedOdialysis

D.OTheyOseparateOrapidlyO-
OANSWEROB.OMostOlyophilicOcolloidsOareOorganicOmoleculesO(includingOgelatinOandOacacia);OtheyOspontane

ouslyOformOcolloidalOsolutionsOandOtendOtoObeOviscous.ODispersionOofOlyophilicOcolloidsOisOstableOinOtheOpr
esenceOofOelectrolytes



WhichOofOtheOfollowingOisOnotOtrueOforOtabletOformulations?



A.OAOdisintegratingOagentOpromotesOgranuleOflow

B.OLubricantsOpreventOadherenceOofOgranulesOtoOtheOpunchOfacesOofOtheOtabletingOmachine

C.OGlidantsOpromoteOflowOofOtheOgranules

D.OBindingOagentsOareOusedOforOadhesionOofOpowderOintoOgranulesO-
OANSWEROA.ODisintegratingOagentsOareOaddedOtoOtheOtabletsOtoOpromoteObreakupOofOtheOtabletsOwhenOpl

acedOinOtheOaqueousOenvironment.OLubricantsOareOrequiredOtoOpreventOadherenceOofOtheOgranulesOtoOth
eOpunchOfacesOandOdies.OGlidantsOareOaddedOtoOtabletOformulationsOtoOimproveOtheOflowOpropertiesOofOth
eOgranulations.OBindingOagentsOareOaddedOtoObindOpowdersOtogetherOinOtheOgranulationOprocess



TheOabsorptionOrateOofOaOdrugOisOmostOrapidOwhenOtheOdrugOisOformulatedOas



A.OaOcontrolled-releaseOproduct

B.OaOhardOgelatinOcapsule

C.OaOcompressedOtablet

D.OaOsolutionO-
OANSWEROD.OForOaOdrugOinOsolution,OnoOdissolutionOisOrequiredObeforeOabsorption.OConsequently,Ocompa

redOwithOotherOdrugOformulations,OaOdrugOinOaqueousOsolutionOhasOtheOhighestObioavailabilityOrateOandOis
OoftenOusedOasOtheOreferenceOpreparationOforOotherOformulations




AccordingOtoOtheONoyes-
WhitneyOequation,OtheOdrugOconcentrationOimmediatelyOatOtheOsolidOsurfaceOwithinOtheOdiffusionOlayerO(
stagnantOlayer)OisOrecognizedOasOthe