PC 707 - Module 1 questions and answers
Pharmacology - Stud of drugs and their action and effects on a living system.
The four processes of pharmacokinetics - Absorption, distribution, metabolism
and excretion.
Absorption - Movement of the drug from the site of administration into the
systemic circulation.
Distribution - Movement of drugs from the systemic circulation to the site of drug
action.
Metabolism - Enzymatic alteration of drug struture.
Excretion - Removal of the drug from the body.
Affinity - Strength of the attraction between a drug and its receptor.
Activation - Drug's ability to cause the receptor to activate after binding to the
site.
,PC 707 - Module 1 questions and answers
Agonists - Drugs that bind to the receptor site and activates the drug.
Antagonists - Drugs that block the action of the endogenous regulatory molecule,
and prevents activation.
If there is not an agonist present... - Administration of an antagonist will have no
observable effect.
Partial-Agonists - Drugs that bind to the receptor site and have only a moderate
expression of the endogenous regulatory molecule.
Competitive Antagonist - Any pharmacologic antagonist that "competes" with the
binding of the agonist at the binding site.
Lipid soluble drugs are absorbed - More rapidly
Lipid soluble drugs can - cross membranes that separate them from blood
Lipid soluble drugs - easily cross the placenta to breastmilk to fetus and infant
, PC 707 - Module 1 questions and answers
blood brain barrier - has tight junctions that prevent drug passage
Only lipid soluble drugs can - transport across the blood-brain barrier without
other transport systems.
Placenta drug transfer - simple diffusion, lipid soluble and non-ionized compounds
cross placenta to infant.
Ionized, highly polar drugs do... - not reach the fetus.
Albumin is the - most important protein to which drugs can bind
Binding between albumin and drugs is - reversible
If a drug is bound to protein it is - inactive
Albumin is too large too - leave the bloodstream
Stopping or starting a drug that bind to plasma proteins changes the amount... - of
other free drug levels of protein bound drugs.
Pharmacology - Stud of drugs and their action and effects on a living system.
The four processes of pharmacokinetics - Absorption, distribution, metabolism
and excretion.
Absorption - Movement of the drug from the site of administration into the
systemic circulation.
Distribution - Movement of drugs from the systemic circulation to the site of drug
action.
Metabolism - Enzymatic alteration of drug struture.
Excretion - Removal of the drug from the body.
Affinity - Strength of the attraction between a drug and its receptor.
Activation - Drug's ability to cause the receptor to activate after binding to the
site.
,PC 707 - Module 1 questions and answers
Agonists - Drugs that bind to the receptor site and activates the drug.
Antagonists - Drugs that block the action of the endogenous regulatory molecule,
and prevents activation.
If there is not an agonist present... - Administration of an antagonist will have no
observable effect.
Partial-Agonists - Drugs that bind to the receptor site and have only a moderate
expression of the endogenous regulatory molecule.
Competitive Antagonist - Any pharmacologic antagonist that "competes" with the
binding of the agonist at the binding site.
Lipid soluble drugs are absorbed - More rapidly
Lipid soluble drugs can - cross membranes that separate them from blood
Lipid soluble drugs - easily cross the placenta to breastmilk to fetus and infant
, PC 707 - Module 1 questions and answers
blood brain barrier - has tight junctions that prevent drug passage
Only lipid soluble drugs can - transport across the blood-brain barrier without
other transport systems.
Placenta drug transfer - simple diffusion, lipid soluble and non-ionized compounds
cross placenta to infant.
Ionized, highly polar drugs do... - not reach the fetus.
Albumin is the - most important protein to which drugs can bind
Binding between albumin and drugs is - reversible
If a drug is bound to protein it is - inactive
Albumin is too large too - leave the bloodstream
Stopping or starting a drug that bind to plasma proteins changes the amount... - of
other free drug levels of protein bound drugs.
