ASCP CGMBS Exam
Study Questions
and Complete
Solutions Graded
A+
Denning [Date] [Course title]
, BCR;ABL1 fusion protein - Answer: t(9;22)(q34;q11)
Acute Promyelocytic Leukemia (APL) - Answer: t(15;17) a fusion of PML and RARA
Burkitt's Lymphoma - Answer: t(8;14) the breakpoints on chr.8 are spread of 190 kbp region 5' to and
within the C-MY C gene
Follicular Cell Lymphoma (FCL) - Answer: t(14;18) translocation disregulate BCL2, which inhibits
apoptosis in B lymphocytes, which leads to survival of genetically damaged cells
Mantle Cell (MCL) - Answer: t(11;14) translocation increases expression of CCND1
Chronic Myelogenous Leukemia (CML) - Answer: t(9;22) aka Philadelphia Chromosome, translocation
occurs within two genes: the breakpoint cluster region (BCR) on chr.22 and the cellular counter part of
the Abelson Leukemia virus tyrosine kinase (c-abl) on chr.9
Marginal Zone Lymphoma - Answer: t(11;18)
Vorinostat/Zolina - Answer: second-line drug for cutaneous T-cell lymphoma. Treatments are often
used in combination with phototherapy and chemotherapy
Irinotecan - Answer: UGT1A1 - Prevents DNA from unwinding by inhibition of topoisomerase 1
Warfarin (Coumadin) - Answer: CYP2C9 and VKORC1 - Vitamin K antagonist; metabolized primarily via
oxidation in the liver by CYP2C9 and exerts its anticoagulant effect by inhibiting the protein vitamin
epoxide reductase complex, subunit 1 (VKORC1)
Tamoxifen - Answer: CYP2D6 - anti estrogen therapy for hormone receptor-positive breast cancer in
pre-menopausal women
Azathioprine - Answer: TPMT - immunosuppresive used in organ transplant
Study Questions
and Complete
Solutions Graded
A+
Denning [Date] [Course title]
, BCR;ABL1 fusion protein - Answer: t(9;22)(q34;q11)
Acute Promyelocytic Leukemia (APL) - Answer: t(15;17) a fusion of PML and RARA
Burkitt's Lymphoma - Answer: t(8;14) the breakpoints on chr.8 are spread of 190 kbp region 5' to and
within the C-MY C gene
Follicular Cell Lymphoma (FCL) - Answer: t(14;18) translocation disregulate BCL2, which inhibits
apoptosis in B lymphocytes, which leads to survival of genetically damaged cells
Mantle Cell (MCL) - Answer: t(11;14) translocation increases expression of CCND1
Chronic Myelogenous Leukemia (CML) - Answer: t(9;22) aka Philadelphia Chromosome, translocation
occurs within two genes: the breakpoint cluster region (BCR) on chr.22 and the cellular counter part of
the Abelson Leukemia virus tyrosine kinase (c-abl) on chr.9
Marginal Zone Lymphoma - Answer: t(11;18)
Vorinostat/Zolina - Answer: second-line drug for cutaneous T-cell lymphoma. Treatments are often
used in combination with phototherapy and chemotherapy
Irinotecan - Answer: UGT1A1 - Prevents DNA from unwinding by inhibition of topoisomerase 1
Warfarin (Coumadin) - Answer: CYP2C9 and VKORC1 - Vitamin K antagonist; metabolized primarily via
oxidation in the liver by CYP2C9 and exerts its anticoagulant effect by inhibiting the protein vitamin
epoxide reductase complex, subunit 1 (VKORC1)
Tamoxifen - Answer: CYP2D6 - anti estrogen therapy for hormone receptor-positive breast cancer in
pre-menopausal women
Azathioprine - Answer: TPMT - immunosuppresive used in organ transplant
