Laboratory Markers of Inflammation:
ESR and CRP
Are positive acute-phase reactant proteins secreted into the blood in an increased
amount or decreased amount in response to inflammation? correct answers increased
amount
What are some various physiological immune functions of a positive acute phase
reaction? correct answers 1. directly destroys microbes
2. activates immune system by increased vascular permeability or by recruiting
phagocytic cells.
3. inhibits growth of microbes
4. limits infection by trapping pathogens in blood clots
5. protects tissues from microbial enzymes
In NEGATIVE acute phase reactions, production is ___________ in response to
inflammation correct answers reduced
What is production of acute phase reactant proteins reduced in negative acute phase
reactions? correct answers in order to provide more amino acid substrate for the
production of positive acute phase proteins (ex: albumin, transferrin, antithrombin)
What is a collagen-vascular disorder that is an autoimmune connective tissue disorder
that causes inflammation and elevated inflammatory markers? correct answers
rheumatoid arthritis
What is a collagen vascular disorder, vasculitic disorder that causes inflammation and
elevated inflammatory markers? (2 of them) correct answers Temporal arteritis,
polymyaglia rheumatica
What are other autoimmune disorders that can cause inflammation and elevated
inflammatory markers? correct answers systemic lupus erythematosus (SLE)
What is a commonly performed, simple + inexpensive test that measures the distance
that RBCs have fallen after one hour? correct answers Erythrocyte sedimentation rate
(ESR)
Does ESR directly measure the presence of inflammation in the body? correct answers
no
is ESR a very specific test? correct answers NO-does not reveal the CAUSE of
inflammation
ESR and CRP
Are positive acute-phase reactant proteins secreted into the blood in an increased
amount or decreased amount in response to inflammation? correct answers increased
amount
What are some various physiological immune functions of a positive acute phase
reaction? correct answers 1. directly destroys microbes
2. activates immune system by increased vascular permeability or by recruiting
phagocytic cells.
3. inhibits growth of microbes
4. limits infection by trapping pathogens in blood clots
5. protects tissues from microbial enzymes
In NEGATIVE acute phase reactions, production is ___________ in response to
inflammation correct answers reduced
What is production of acute phase reactant proteins reduced in negative acute phase
reactions? correct answers in order to provide more amino acid substrate for the
production of positive acute phase proteins (ex: albumin, transferrin, antithrombin)
What is a collagen-vascular disorder that is an autoimmune connective tissue disorder
that causes inflammation and elevated inflammatory markers? correct answers
rheumatoid arthritis
What is a collagen vascular disorder, vasculitic disorder that causes inflammation and
elevated inflammatory markers? (2 of them) correct answers Temporal arteritis,
polymyaglia rheumatica
What are other autoimmune disorders that can cause inflammation and elevated
inflammatory markers? correct answers systemic lupus erythematosus (SLE)
What is a commonly performed, simple + inexpensive test that measures the distance
that RBCs have fallen after one hour? correct answers Erythrocyte sedimentation rate
(ESR)
Does ESR directly measure the presence of inflammation in the body? correct answers
no
is ESR a very specific test? correct answers NO-does not reveal the CAUSE of
inflammation
