Advanced Pathophysiology |LATEST
VERSION |NEW UPDATE |GUARANTEED
PASS|2024-2025 |BEST STUDYING
MATERIAL WITH 100+ QUESTIONS
what happens to bone in OA
- ANSWER because cartilage thins, the underlying subchrondral bone is
unprotected and becomes sclerotic
rheumatoid arthritis vs. osteoarthritis
- ANSWER Rheumatoid arthritis is autoimmune and is always on both sides. May
begin at any time, rapid progression, joints are painful/swollen/stiff.
Osteoarthritis is due to wear and tear, and is only on a specific joint. OA=One Arm.
Occurs later in life, slow progression, joints ache and are tender with little to no
swelling
fibromyalgia
- ANSWER chronic condition with widespread aching and pain in the muscles and
fibrous soft tissue
Myotonic Channelopathies
- ANSWER delayed muscle relaxation
treatment for myotonia
,- ANSWER removing extracellular chloride
central core disease
- ANSWER mutations in ryanodine receptors that affects calcium channels
mcardle disease
- ANSWER Glycogen storage disease affecting the muscles causing fatigue. caused
by lack of muscle phosphorylase which is needed to breakdown glycogen.
acid maltase deficiency
- ANSWER accumulation of glycogen in lysosomes
myoadenylate deaminase deficiency
- ANSWER Exercise intolerance with normal production of lactic acid.
myoadenylate deaminase is the catalytic enzyme that forms phosphocreatine and
ATP during exercise
polymyositis and dermatomyositis
- ANSWER inflammation of connective tissue and muscle fibers
what is polymyositis mediated by
- ANSWER t cells
tendon tear
- ANSWER strain
, ligament tear
- ANSWER sprain
Epicondylopathy
- ANSWER degeneration of a tendon where it attaches to a bone
how do glucocorticoids affect bone density
- ANSWER increase RANKL expression and inhibit OPG production by osteoblasts
RANKL
- ANSWER a chemical that stimulates production of more osteoclasts
OPG (osteoprotegerin)
- ANSWER Secreted by osteoblasts and protects bone from excessive resorption
by binding to RANKL
sporadic paget disease involves overexpression of
- ANSWER RANKL
lyme disease test can be negative for how long
- ANSWER first 3 weeks after infx
lyme disease pathophysiology
VERSION |NEW UPDATE |GUARANTEED
PASS|2024-2025 |BEST STUDYING
MATERIAL WITH 100+ QUESTIONS
what happens to bone in OA
- ANSWER because cartilage thins, the underlying subchrondral bone is
unprotected and becomes sclerotic
rheumatoid arthritis vs. osteoarthritis
- ANSWER Rheumatoid arthritis is autoimmune and is always on both sides. May
begin at any time, rapid progression, joints are painful/swollen/stiff.
Osteoarthritis is due to wear and tear, and is only on a specific joint. OA=One Arm.
Occurs later in life, slow progression, joints ache and are tender with little to no
swelling
fibromyalgia
- ANSWER chronic condition with widespread aching and pain in the muscles and
fibrous soft tissue
Myotonic Channelopathies
- ANSWER delayed muscle relaxation
treatment for myotonia
,- ANSWER removing extracellular chloride
central core disease
- ANSWER mutations in ryanodine receptors that affects calcium channels
mcardle disease
- ANSWER Glycogen storage disease affecting the muscles causing fatigue. caused
by lack of muscle phosphorylase which is needed to breakdown glycogen.
acid maltase deficiency
- ANSWER accumulation of glycogen in lysosomes
myoadenylate deaminase deficiency
- ANSWER Exercise intolerance with normal production of lactic acid.
myoadenylate deaminase is the catalytic enzyme that forms phosphocreatine and
ATP during exercise
polymyositis and dermatomyositis
- ANSWER inflammation of connective tissue and muscle fibers
what is polymyositis mediated by
- ANSWER t cells
tendon tear
- ANSWER strain
, ligament tear
- ANSWER sprain
Epicondylopathy
- ANSWER degeneration of a tendon where it attaches to a bone
how do glucocorticoids affect bone density
- ANSWER increase RANKL expression and inhibit OPG production by osteoblasts
RANKL
- ANSWER a chemical that stimulates production of more osteoclasts
OPG (osteoprotegerin)
- ANSWER Secreted by osteoblasts and protects bone from excessive resorption
by binding to RANKL
sporadic paget disease involves overexpression of
- ANSWER RANKL
lyme disease test can be negative for how long
- ANSWER first 3 weeks after infx
lyme disease pathophysiology
