ONS CHEMOTHERAPY IMMUNOTHERAPY CERTIFICATE QUESTIONS WITH CORRECT ANSWERS

ONS CHEMOTHERAPY
IMMUNOTHERAPY CERTIFICATE
QUESTIONS WITH CORRECT ANSWERS
3amajoraphasesaofacelladivision:a-aans--Interphase
Mitoticaphase
Cytokinesis

3astepsaofainterphase:a-aans--Firstagrowthaphasea(G1)
Synthesisaphasea(Saphase)
Secondagrowthaphasea(G2)

4aphasesaofamitosis:a-aans--Prophase
Metaphase
Anaphase
Telophase

Innateaimmunity:a-aans--Non-specificaresponse,aeither:
1.aBarriera(skin,amucousamembranes,afloraaofaskin/gut)
2.aCellularacomponentsa(phagocytes,anaturalakilleracells,agranulocytes,amacrophages)

Adaptiveaimmunity:a-aans--
Followsainnateaimmunityaifaunsuccessful.aMemoryaimmunity,aincluding:
1.aHumoralaimmunitya(productionaofaantibodiesaoraimmunoglobulins)
2.aCellamediatedaimmunitya(dependentauponaTacells)
3.aRegulatoryaTa-cellsa(preventaautoimmuneareactionsaandalimitainflammatoryaresponses)

Defineamutationsa-aans--Variationsainatheanucleotideasequenceaofaaagene

3amainagoalsaofatreatment:a-aans--Cure
Control
Palliation

Defineaneoadjuvantatherapya-aans--
Treatmentaisagivenaprioratoasurgeryatoashrinkatheatumor

Defineaadjuvantatherapya-aans--
Additionalacanceratreatmentagivenaafteratheaprimaryatreatmentatoaloweratheariskathatatheac
ancerareoccur

Defineaconditioning/preparativeatherapya-aans--
Treatmentsausedatoaprepareaaapatientaforastemacellatransplantation

, 2atypesaofaconditioningatherapies:a-aans--Myeloablative
Nonmyeloablative

Defineadoseadensitya-aans--Drugadoseaperaunitaofatime

Defineadoseaintensitya-aans--Amountaofadrugadeliveredaoveratime

Howaisarelativeadoseaintensitya(RDI)acalculated?a-aans--
ByacomparingatheadoseathatatheapatientaACTUALLYareceivedatoatheaplannedadoseaofathea
standardaregimen

Howadoaalkylatingaagentsawork?a-aans--
ByacausingaaabreakainatheaDNAahelixastrand,ainterferingawithaDNAareplicationaandacausing
acelladeath



3asubcategoriesaofaalkylatingaagents:a-aans--1.aNitrogenamustards
2.aPlatinum-
basedaagentsa(doanotapossessaanaalkylagroupabutastillatermedaalkylatingaagentsaasatheyaw
orkasimilarly)
3.aNitrosoureas

Mostacommonasubcategoryaofaalkylatingaagents:a-aans--Nitrogenamustards

Commonaalkylatingaagents:a-aans--Cyclophosphamidea(Cytoxan)
Ifosfamidea(Ifex)
Bendamustinea(Treanda)

Commonaplatinum-basedaagents:a-aans--Cisplatina(Platinol)
Carboplatina(Paraplatin)

Whataisauniqueaaboutanitrosoureasaagents?a-aans--Ableatoacrossatheablood-
brainabarrier;acanabeaeffectiveainatreatingasomeabrainatumors

Commonanitrosoureasaagents:a-aans--Carmustinea(BiCNU)
Lomustinea(CeeNu)
Streptozocina(Zanosar)

Hypersensitivityacanaoccurawithalateadosesaof:a-aans--Carboplatin

Theseaagentsaareatypicallyacategorizedaasahighlyaemetogenic:a-aans--1.aAlkylatingaagents
2.aNitrosoureas

Pre-administrationalabsaforaalkylatingaagentsaandanitrosoureas:a-aans--BUN
Creatinine
CBCaw/adiff