AAMC MCAT Practice Exam 1 With
Correctly Explained Questions And
Answers 2024
In mthe mchromatography mof mthe mreaction mmixture, mwater mabsorbed mon mcellulose
mfunctioned mas mthe mstationary mphase. mWhat mwas mthe mprincipal mfactor mdetermining mthe
mmigration mof mindividual mcomponents min mthe msample?
A) mHydrogen mbonding
B) mSolute mconcentration
C) mStationary mphase mconcentration
D) mThickness mof mpaper m- mcorrect manswer.A) mHydrogen mbonding m
The manswer mto mthis mquestion mis mA mbecause mthe mrelative mamount mof mhydrogen mbonding
mto mthe mstationary mphase mwill mdetermine mthe mrelative mrate mof mmigration mof mthe mvarious
mcomponents min mthe msample.
What massumption mis mbeing mmade mif mscientists mconclude mthat maspartic macid mwas
mformed mby mthe mprebiological msynthesis min mthe mpassage?
A) mAspartic macid mis munstable mat mtemperatures mbelow m150 mdegrees mC. m
B) mAll mof mthe mmalic macid munderwent mthe mdehydration mreaction mto mform mfumaric/maleic
macid. m
C) mCompound mA mand mcyanide mwere mavailable mon mprimitive mEarth. m
D) mThe mreaction mbetween mammonia mand mfumaric macid mwas mcatalyzed mby mthe
mpresence mof mwater. m- mcorrect manswer.C) mCompound mA mand mcyanide mwere mavailable
mon mprimitive mEarth. m
he manswer mto mthis mquestion mis mC msince, min morder mfor mthe mexperimental mreaction
msequence mto mbe mrelevant mto mthe mprimordial mformation mof maspartic macid, mthe mstarting
mmaterials mused m(Compound mA mand mcyanide) mare massumed mto mhave mbeen mavailable.
According mto mthe mdeveloped mchromatography mplate mshown mbelow, mwhat mis mthe
mapproximate mRf mvalue mof maspartic macid?
,aspartic macid m= m2
solvent mfront m= m10 m
A) m0.20
B) m0.50
C) m5
D) m10 m- mcorrect manswer.The manswer mto mthis mquestion mis mA m(0.20) mbecause mRf mis mthe
mratio mof mthe mdistance mtravelled mby mthe manalyte mrelative mto mthe msolvent mfront mduring ma
mchromatographic mseparation. mAspartic macid mtravelled mtwo munits, mwhile mthe msolvent
mfront mtravelled mten munits, mgiving man mRf mof m2/10 m= m0.20 mfor maspartic macid.
Which mof mthe mfollowing mstatements mdoes mNOT mcorrectly mdescribe mthe mdehydration mof
mmalic macid mto mfumaric macid mand mmaleic macid? m
A) mThe mreaction moccurs mmost mreadily mwith mtertiary malcohols. m
B) mThe mreaction minvolves mthe mloss mof ma mwater mmolecule. m
C) mThe mreaction mhas ma mcarbocation mintermediate.
D) mThe mreaction mis mstereospecific. m- mcorrect manswer.D) mThe mreaction mis mstereospecific.
The manswer mto mthis mquestion mis mD mbecause mthe mfact mthat mboth mfumaric mand mmaleic
macid mare mproduced mmeans mthat mthe mdehydration mof mmalic macid mis mNOT mstereospecific.
What mtype mof mfunctional mgroup mis mformed mwhen maspartic macid mreacts mwith manother
mamino macid mto mform ma mpeptide mbond? m
A) mAn mamine mgroup m
B) mAn maldehyde mgroup
C) mAn mamide mgroup
D) mA mcarboxyl mgroup m- mcorrect manswer.C) mAn mamide mgroup
The manswer mto mthis mquestion mis mC mbecause mthe mfunctional mgroup mthat mforms mduring
mpeptide mbond mformation mis mknown mas man mamide mgroup.
If m2-pentanol mreplaces m1-pentanol min mthe mreaction mshown min mFigure m3 m(SN2), mthe mrate
mof msubstitution mis mless mbecause: m
A) mthe mC-O mbond min m2-pentanol mis mstronger mthan mthe mC-O mbond min m1-pentanol.
B) mthere mis ma mcompeting melimination mreaction mthat mslows mthe mrate mof msubstitution.
C) mthere mis mmore msteric mhindrance mat mthe moxygen matom min m2-pentanol mthan min m1-
pentanol, mmaking mprotonation mless mlikely.
D) mthere mis mmore msteric mhindrance mat mthe m2-position mof m2-pentanol mthan mat mthe m1-
position mof m1-pentanol. m- mcorrect manswer.D) mthere mis mmore msteric mhindrance mat mthe m2-
position mof m2-pentanol mthan mat mthe m1-position mof m1-pentanol.
The manswer mto mthis mquestion mis mD mbecause mthe mrate mof msubstitution mof mprotonated
malcohols mis msubject mto msteric mhindrance. mThis minhibits mthe mability mof mnucleophiles mto
mcollide mwith mthe mreacting melectrophilic mcenter mand mslows mthe mrate mof mreaction.
,If ma msolution mcontaining mthe mcompounds mshown min mFigure m4, mis minjected minto ma mgas-
liquid mchromatograph, mthe mfirst mpeak mobserved min mthe mgc mtrace mis mattributable mto
mwhich mcompound?
A) mMethyl-2-butanol
B) mMethyl-2-butene
C) mChloro-2-methylbutane
D) mBromo-2-mehtylbutane m- mcorrect manswer.B) mMethyl-2-butene
The manswer mto mthis mquestion mis mB mbecause m2-methyl-2-butene mwill mexhibit mthe mlowest
mmolecular mweight mand malso mthe mweakest mintermolecular mforces mof mattraction. mThis
msubstance mwill mtherefore mmigrate mthe mfastest mand mbe mthe mfirst mpeak min mthe mgas
mchromatograph m(gc) mtrace.
R mvs. mS mstereochemistry* m- mcorrect manswer.R m= mclockwise
C m= mcounter-clockwise
Acetic macid mand methanol mreact mto mform man mester mproduct mas mshown mbelow. m
In mdetermining mwhich mreactant mloses mthe m-OH mgroup, mwhich mof mthe mfollowing misotopic
msubstitutions mwould mbe mmost museful?
A) mReplace mthe macidic mH mof macetic macid mwith mD
B) mReplace mthe malcoholic mH mof methanol mwith mD. m
C) mReplace mthe mcarbonyl moxygen mof macetic macid mwith mO-18. m
D) mReplace mthe mhydroxyl moxygen mof methanol mwith mO-18. m- mcorrect manswer.D) mReplace
mthe mhydroxyl moxygen mof methanol mwith mO-18.
The manswer mto mthis mquestion mis mD mbecause mthis mexperiment minvolves mlabeling ma
mgroup mwhich mdoes mnot mexchange mwith mother mgroups mpresent mprior mto m reaction mand
mwill mtherefore mgive minformation mabout mthe mtrue midentity mof mthe mgroups, mwhich mare
mexchanged mduring mthe mreaction.
A mperson mwhose meye mhas ma mlens-to-retina mdistance mof m2.0 mcm, mcan monly mclearly msee
mobjects mthat mare mcloser mthan m1.0 mm maway. mWhat mis mthe mstrength mS mof mthe mperson's
meye mlens? m(Note: mUse mthe mthin mlens mformula m1/O m+ m1/I m= mS) m
A) m-50 mD
B) m-10 mD
C) m51 mD
D) m55 mD m- mcorrect manswer.C) m51 mD
mThe manswer mto mthis mquestion mis mC mbecause mthe mstrength mof mthe meye mlens mis mequal mto
mthe minverse mof mthe mfocal mlength mof mthe meye mlens. mIts mnumerical mvalue m is mgiven mby m(1
mm)-1+(0.02 mm)-1=1 mD+50 mD=51 mD.
, Which mstatement mcorrectly mdescribes mhow menzymes maffect mchemical mreactions?
mStabilization mof: m
A) mthe msubstrate mchanges mthe mfree menergy mof mthe mreaction.
B) mthe mtransition mstate mchanges mthe mfree menergy mof mthe mreaction.
C) mthe msubstrate mchanges mthe mactivation menergy mof mthe mreaction.
D) mthe mtransition mstate mchanges mthe mactivation menergy mof mthe mreaction. m- mcorrect
manswer.D) mthe mtransition mstate mchanges mthe mactivation menergy mof mthe mreaction.
The manswer mis mD mbecause mthe mstabilization mof mthe mtransition mstate, mnot mthe msubstrate,
mprovides mbinding menergy mthat mis mused mto mlower mthe mactivation menergy.
Which mof mthe mfollowing mwill mdecrease mthe mpercentage mionization mof m1.0 mM macetic macid,
mCH3CO2H(aq)?*
A) mChlorinating mthe mCH3 mgroup
B) mDiluting mthe msolution m
C) mAdding mconcentrated mHCl m(aq)
D) mAdding ma mdrop mof mbasic mindicator m- mcorrect manswer.C) mAdding mconcentrated mHCl
m(aq)
The manswer mto mthis mquestion mis mC mbecause mHCl mis ma mstrong macid mthat mwill mincrease
mthe mamount mof mH+ min msolution mand mthus mdecrease mthe mpercentage mof mCH3CO2H mthat
mionizes.
When mthe mcurrent min mthe mmicro-robot's mcircuit mincreases mand mthe mresistance mof mthe
mcircuit mremains mconstant, mthe mvoltage mof mthe mcircuit:
A) mdecreases
B) mincreases
C) mis mconstant m
D) mis mzero m- mcorrect manswer.B) mincreases
V m= mIR
The manswer mto mthis mquestion mis mB mbecause maccording mto mOhm's mlaw, mcurrent mis mequal
mto mvoltage mdivided mby mresistance. mIf mcurrent mincreases mand mresistance mis mconstant,
mthen mvoltage mincreases mas mwell.
Knowing mthat mthe mspeed mof mlight min mthe mvitreous mhumor mis m2.1 m× m108 mm/s, mwhat mis
mthe mindex mof mrefraction mof mthe mvitreous mhumor? m(Note: mThe mspeed mof mlight min ma
mvacuum mis m3.0 m× m108 mm/s.)
A) m0.7
B) m1.4
C) m2.1
D) m3.0 m- mcorrect manswer.B) m1.4
Correctly Explained Questions And
Answers 2024
In mthe mchromatography mof mthe mreaction mmixture, mwater mabsorbed mon mcellulose
mfunctioned mas mthe mstationary mphase. mWhat mwas mthe mprincipal mfactor mdetermining mthe
mmigration mof mindividual mcomponents min mthe msample?
A) mHydrogen mbonding
B) mSolute mconcentration
C) mStationary mphase mconcentration
D) mThickness mof mpaper m- mcorrect manswer.A) mHydrogen mbonding m
The manswer mto mthis mquestion mis mA mbecause mthe mrelative mamount mof mhydrogen mbonding
mto mthe mstationary mphase mwill mdetermine mthe mrelative mrate mof mmigration mof mthe mvarious
mcomponents min mthe msample.
What massumption mis mbeing mmade mif mscientists mconclude mthat maspartic macid mwas
mformed mby mthe mprebiological msynthesis min mthe mpassage?
A) mAspartic macid mis munstable mat mtemperatures mbelow m150 mdegrees mC. m
B) mAll mof mthe mmalic macid munderwent mthe mdehydration mreaction mto mform mfumaric/maleic
macid. m
C) mCompound mA mand mcyanide mwere mavailable mon mprimitive mEarth. m
D) mThe mreaction mbetween mammonia mand mfumaric macid mwas mcatalyzed mby mthe
mpresence mof mwater. m- mcorrect manswer.C) mCompound mA mand mcyanide mwere mavailable
mon mprimitive mEarth. m
he manswer mto mthis mquestion mis mC msince, min morder mfor mthe mexperimental mreaction
msequence mto mbe mrelevant mto mthe mprimordial mformation mof maspartic macid, mthe mstarting
mmaterials mused m(Compound mA mand mcyanide) mare massumed mto mhave mbeen mavailable.
According mto mthe mdeveloped mchromatography mplate mshown mbelow, mwhat mis mthe
mapproximate mRf mvalue mof maspartic macid?
,aspartic macid m= m2
solvent mfront m= m10 m
A) m0.20
B) m0.50
C) m5
D) m10 m- mcorrect manswer.The manswer mto mthis mquestion mis mA m(0.20) mbecause mRf mis mthe
mratio mof mthe mdistance mtravelled mby mthe manalyte mrelative mto mthe msolvent mfront mduring ma
mchromatographic mseparation. mAspartic macid mtravelled mtwo munits, mwhile mthe msolvent
mfront mtravelled mten munits, mgiving man mRf mof m2/10 m= m0.20 mfor maspartic macid.
Which mof mthe mfollowing mstatements mdoes mNOT mcorrectly mdescribe mthe mdehydration mof
mmalic macid mto mfumaric macid mand mmaleic macid? m
A) mThe mreaction moccurs mmost mreadily mwith mtertiary malcohols. m
B) mThe mreaction minvolves mthe mloss mof ma mwater mmolecule. m
C) mThe mreaction mhas ma mcarbocation mintermediate.
D) mThe mreaction mis mstereospecific. m- mcorrect manswer.D) mThe mreaction mis mstereospecific.
The manswer mto mthis mquestion mis mD mbecause mthe mfact mthat mboth mfumaric mand mmaleic
macid mare mproduced mmeans mthat mthe mdehydration mof mmalic macid mis mNOT mstereospecific.
What mtype mof mfunctional mgroup mis mformed mwhen maspartic macid mreacts mwith manother
mamino macid mto mform ma mpeptide mbond? m
A) mAn mamine mgroup m
B) mAn maldehyde mgroup
C) mAn mamide mgroup
D) mA mcarboxyl mgroup m- mcorrect manswer.C) mAn mamide mgroup
The manswer mto mthis mquestion mis mC mbecause mthe mfunctional mgroup mthat mforms mduring
mpeptide mbond mformation mis mknown mas man mamide mgroup.
If m2-pentanol mreplaces m1-pentanol min mthe mreaction mshown min mFigure m3 m(SN2), mthe mrate
mof msubstitution mis mless mbecause: m
A) mthe mC-O mbond min m2-pentanol mis mstronger mthan mthe mC-O mbond min m1-pentanol.
B) mthere mis ma mcompeting melimination mreaction mthat mslows mthe mrate mof msubstitution.
C) mthere mis mmore msteric mhindrance mat mthe moxygen matom min m2-pentanol mthan min m1-
pentanol, mmaking mprotonation mless mlikely.
D) mthere mis mmore msteric mhindrance mat mthe m2-position mof m2-pentanol mthan mat mthe m1-
position mof m1-pentanol. m- mcorrect manswer.D) mthere mis mmore msteric mhindrance mat mthe m2-
position mof m2-pentanol mthan mat mthe m1-position mof m1-pentanol.
The manswer mto mthis mquestion mis mD mbecause mthe mrate mof msubstitution mof mprotonated
malcohols mis msubject mto msteric mhindrance. mThis minhibits mthe mability mof mnucleophiles mto
mcollide mwith mthe mreacting melectrophilic mcenter mand mslows mthe mrate mof mreaction.
,If ma msolution mcontaining mthe mcompounds mshown min mFigure m4, mis minjected minto ma mgas-
liquid mchromatograph, mthe mfirst mpeak mobserved min mthe mgc mtrace mis mattributable mto
mwhich mcompound?
A) mMethyl-2-butanol
B) mMethyl-2-butene
C) mChloro-2-methylbutane
D) mBromo-2-mehtylbutane m- mcorrect manswer.B) mMethyl-2-butene
The manswer mto mthis mquestion mis mB mbecause m2-methyl-2-butene mwill mexhibit mthe mlowest
mmolecular mweight mand malso mthe mweakest mintermolecular mforces mof mattraction. mThis
msubstance mwill mtherefore mmigrate mthe mfastest mand mbe mthe mfirst mpeak min mthe mgas
mchromatograph m(gc) mtrace.
R mvs. mS mstereochemistry* m- mcorrect manswer.R m= mclockwise
C m= mcounter-clockwise
Acetic macid mand methanol mreact mto mform man mester mproduct mas mshown mbelow. m
In mdetermining mwhich mreactant mloses mthe m-OH mgroup, mwhich mof mthe mfollowing misotopic
msubstitutions mwould mbe mmost museful?
A) mReplace mthe macidic mH mof macetic macid mwith mD
B) mReplace mthe malcoholic mH mof methanol mwith mD. m
C) mReplace mthe mcarbonyl moxygen mof macetic macid mwith mO-18. m
D) mReplace mthe mhydroxyl moxygen mof methanol mwith mO-18. m- mcorrect manswer.D) mReplace
mthe mhydroxyl moxygen mof methanol mwith mO-18.
The manswer mto mthis mquestion mis mD mbecause mthis mexperiment minvolves mlabeling ma
mgroup mwhich mdoes mnot mexchange mwith mother mgroups mpresent mprior mto m reaction mand
mwill mtherefore mgive minformation mabout mthe mtrue midentity mof mthe mgroups, mwhich mare
mexchanged mduring mthe mreaction.
A mperson mwhose meye mhas ma mlens-to-retina mdistance mof m2.0 mcm, mcan monly mclearly msee
mobjects mthat mare mcloser mthan m1.0 mm maway. mWhat mis mthe mstrength mS mof mthe mperson's
meye mlens? m(Note: mUse mthe mthin mlens mformula m1/O m+ m1/I m= mS) m
A) m-50 mD
B) m-10 mD
C) m51 mD
D) m55 mD m- mcorrect manswer.C) m51 mD
mThe manswer mto mthis mquestion mis mC mbecause mthe mstrength mof mthe meye mlens mis mequal mto
mthe minverse mof mthe mfocal mlength mof mthe meye mlens. mIts mnumerical mvalue m is mgiven mby m(1
mm)-1+(0.02 mm)-1=1 mD+50 mD=51 mD.
, Which mstatement mcorrectly mdescribes mhow menzymes maffect mchemical mreactions?
mStabilization mof: m
A) mthe msubstrate mchanges mthe mfree menergy mof mthe mreaction.
B) mthe mtransition mstate mchanges mthe mfree menergy mof mthe mreaction.
C) mthe msubstrate mchanges mthe mactivation menergy mof mthe mreaction.
D) mthe mtransition mstate mchanges mthe mactivation menergy mof mthe mreaction. m- mcorrect
manswer.D) mthe mtransition mstate mchanges mthe mactivation menergy mof mthe mreaction.
The manswer mis mD mbecause mthe mstabilization mof mthe mtransition mstate, mnot mthe msubstrate,
mprovides mbinding menergy mthat mis mused mto mlower mthe mactivation menergy.
Which mof mthe mfollowing mwill mdecrease mthe mpercentage mionization mof m1.0 mM macetic macid,
mCH3CO2H(aq)?*
A) mChlorinating mthe mCH3 mgroup
B) mDiluting mthe msolution m
C) mAdding mconcentrated mHCl m(aq)
D) mAdding ma mdrop mof mbasic mindicator m- mcorrect manswer.C) mAdding mconcentrated mHCl
m(aq)
The manswer mto mthis mquestion mis mC mbecause mHCl mis ma mstrong macid mthat mwill mincrease
mthe mamount mof mH+ min msolution mand mthus mdecrease mthe mpercentage mof mCH3CO2H mthat
mionizes.
When mthe mcurrent min mthe mmicro-robot's mcircuit mincreases mand mthe mresistance mof mthe
mcircuit mremains mconstant, mthe mvoltage mof mthe mcircuit:
A) mdecreases
B) mincreases
C) mis mconstant m
D) mis mzero m- mcorrect manswer.B) mincreases
V m= mIR
The manswer mto mthis mquestion mis mB mbecause maccording mto mOhm's mlaw, mcurrent mis mequal
mto mvoltage mdivided mby mresistance. mIf mcurrent mincreases mand mresistance mis mconstant,
mthen mvoltage mincreases mas mwell.
Knowing mthat mthe mspeed mof mlight min mthe mvitreous mhumor mis m2.1 m× m108 mm/s, mwhat mis
mthe mindex mof mrefraction mof mthe mvitreous mhumor? m(Note: mThe mspeed mof mlight min ma
mvacuum mis m3.0 m× m108 mm/s.)
A) m0.7
B) m1.4
C) m2.1
D) m3.0 m- mcorrect manswer.B) m1.4
