Test Bank For Netter's Essential Physiology 3rd Edition
Chapter 01: The Cell and Fluid Homeostasis
Chapter 01: The Cell and Fluid Homeostasis
Test Bank
Multiple Choice
1. A normal, healthy 23-year-old man weighs 90 kg. What is the most likely value of the
volume of his interstitial fluid?
A. 54 L
B. 36 L
C. 18 L
D. 13.5 L
E. 4.5 L
ANS: D; body water = 90 kg × 60% × 1 L/kg = 54 L, extracellular fluid = 1/3 × 54 L = 18 L,
interstitial fluid (3/4 of extracellular fluid) = 3/4 × 18 L = 13.5 L (page 6).
2. Which of the following statements concerning body water and electrolytes is true?
A. Na+ is the primary extracellular anion.
B. The Na+/K+ ATPase pumps Na+ into and K+ out of the cell.
C. Leakage of K+ contributes to the resting membrane potential.
D. Osmosis involves movement of a solute across a membrane.
E. Cerebral capillaries have greater permeability than glomerular capillaries.
ANS: C (page 4); (A) Na+ is a cation, (B) Na+ is pumped out and K+ is pumped into the cell
(page 3), (D) osmosis involves movement of water (page 5), and (E) glomerular capillaries
have greater permeability than cerebral capillaries (page 8).
1
,Test Bank For Netter's Essential Physiology 3rd Edition
Chapter 01: The Cell and Fluid Homeostasis
3. What is the filtration pressure in a capillary where capillary hydrostatic pressure is 30 mm
Hg, interstitial hydrostatic pressure is 12 mm Hg, capillary oncotic pressure is 8 mm Hg,
and interstitial oncotic pressure is 0 mm Hg? Assume the capillary is impermeable to
proteins.
A. 42 mm Hg
B. 26 mm Hg
C. 10 mm Hg
D. –10 mm Hg
E. –34 mm Hg
ANS: C; filtration pressure = (30 – 12) – 1.0 × (8 – 0) = 10 mm Hg (pages 7, 9).
4. The subject in Question 1 consumes 1.2 L of pure water. Assuming the water is absorbed
and not excreted, what is the increase in the volume of extracellular fluid (ECF) when
steady state is achieved?
A. 1.2 L
B. 0.8 L
C. 0.6 L
D. 0.4 L
E. 0.2 L
ANS: D; when steady state is achieved, the osmolarity of body compartments must be equal.
Since pure water contains no solutes, the water will distribute to body compartments in
2
,Test Bank For Netter's Essential Physiology 3rd Edition
Chapter 01: The Cell and Fluid Homeostasis
proportion to the osmoles in the compartment. Hence, the ECF will receive 1/3 of the water,
or 0.4 L (page 8).
5. A subject receives injections of 12 mg of inulin and 12 mg of Evans blue dye. A short time
later the concentration of inulin is 1 mg/L and the concentration of Evans blue dye is 4
mg/L. What are the volumes of interstitial fluid (ISF) and plasma?
A. ISF = 9 L, plasma = 3 L
B. ISF = 12 L, plasma = 3 L
C. ISF = 9 L, plasma = 4 L
D. ISF = 12 L, plasma = 6 L
E. ISF = 4 L, plasma = 8 L
ANS: A; inulin distributes through the extracellular compartment so the volume is 12 mg/(1
mg/L) = 12 L, while Evans blue dye distributes through the plasma and thus the volume is 12
mg/(4 mg/L) = 3 L. Interstitial volume is ECF – plasma = 12 L – 3 L = 9 L (page 11).
3
, Test Bank For Netter's Essential Physiology 3rd Edition
Chapter 02: Membrane Transport
Chapter 02: Membrane Transport
Test Bank
Multiple Choice
1. Which statement concerning cellular transport is correct?
A. Doubling the thickness of a membrane doubles the rate of simple diffusion.
B. Facilitated diffusion is not dependent on concentration gradients.
C. Na+/K+ ATPase is an example of secondary active transport.
D. Ligand-gated channels use ATP to move molecules against their concentration gradient.
E. Gap junction channels only occur between adjacent cells.
ANS: E (page 15); (A) doubling thickness halves diffusion rate (page 12), (B) facilitated
diffusion depends on concentration gradient, although transport proteins can become
saturated at high solute concentrations (page 12), (C) Na+/K+ ATPase is an example of
primary active transport (page 13), (D) ligand-gated channels provide facilitated diffusion
when activated by the appropriate ligand.
2. Which of the following statements concerning G proteins is true?
A. Gs, Golf, and Gi all increase cAMP.
B. Glucagon and ACTH activate Gi.
C. Gi amplifies the effects of Gs.
D. Gq acts through IP3 and DAG.
E. Gr increases cGMP.
4
Chapter 01: The Cell and Fluid Homeostasis
Chapter 01: The Cell and Fluid Homeostasis
Test Bank
Multiple Choice
1. A normal, healthy 23-year-old man weighs 90 kg. What is the most likely value of the
volume of his interstitial fluid?
A. 54 L
B. 36 L
C. 18 L
D. 13.5 L
E. 4.5 L
ANS: D; body water = 90 kg × 60% × 1 L/kg = 54 L, extracellular fluid = 1/3 × 54 L = 18 L,
interstitial fluid (3/4 of extracellular fluid) = 3/4 × 18 L = 13.5 L (page 6).
2. Which of the following statements concerning body water and electrolytes is true?
A. Na+ is the primary extracellular anion.
B. The Na+/K+ ATPase pumps Na+ into and K+ out of the cell.
C. Leakage of K+ contributes to the resting membrane potential.
D. Osmosis involves movement of a solute across a membrane.
E. Cerebral capillaries have greater permeability than glomerular capillaries.
ANS: C (page 4); (A) Na+ is a cation, (B) Na+ is pumped out and K+ is pumped into the cell
(page 3), (D) osmosis involves movement of water (page 5), and (E) glomerular capillaries
have greater permeability than cerebral capillaries (page 8).
1
,Test Bank For Netter's Essential Physiology 3rd Edition
Chapter 01: The Cell and Fluid Homeostasis
3. What is the filtration pressure in a capillary where capillary hydrostatic pressure is 30 mm
Hg, interstitial hydrostatic pressure is 12 mm Hg, capillary oncotic pressure is 8 mm Hg,
and interstitial oncotic pressure is 0 mm Hg? Assume the capillary is impermeable to
proteins.
A. 42 mm Hg
B. 26 mm Hg
C. 10 mm Hg
D. –10 mm Hg
E. –34 mm Hg
ANS: C; filtration pressure = (30 – 12) – 1.0 × (8 – 0) = 10 mm Hg (pages 7, 9).
4. The subject in Question 1 consumes 1.2 L of pure water. Assuming the water is absorbed
and not excreted, what is the increase in the volume of extracellular fluid (ECF) when
steady state is achieved?
A. 1.2 L
B. 0.8 L
C. 0.6 L
D. 0.4 L
E. 0.2 L
ANS: D; when steady state is achieved, the osmolarity of body compartments must be equal.
Since pure water contains no solutes, the water will distribute to body compartments in
2
,Test Bank For Netter's Essential Physiology 3rd Edition
Chapter 01: The Cell and Fluid Homeostasis
proportion to the osmoles in the compartment. Hence, the ECF will receive 1/3 of the water,
or 0.4 L (page 8).
5. A subject receives injections of 12 mg of inulin and 12 mg of Evans blue dye. A short time
later the concentration of inulin is 1 mg/L and the concentration of Evans blue dye is 4
mg/L. What are the volumes of interstitial fluid (ISF) and plasma?
A. ISF = 9 L, plasma = 3 L
B. ISF = 12 L, plasma = 3 L
C. ISF = 9 L, plasma = 4 L
D. ISF = 12 L, plasma = 6 L
E. ISF = 4 L, plasma = 8 L
ANS: A; inulin distributes through the extracellular compartment so the volume is 12 mg/(1
mg/L) = 12 L, while Evans blue dye distributes through the plasma and thus the volume is 12
mg/(4 mg/L) = 3 L. Interstitial volume is ECF – plasma = 12 L – 3 L = 9 L (page 11).
3
, Test Bank For Netter's Essential Physiology 3rd Edition
Chapter 02: Membrane Transport
Chapter 02: Membrane Transport
Test Bank
Multiple Choice
1. Which statement concerning cellular transport is correct?
A. Doubling the thickness of a membrane doubles the rate of simple diffusion.
B. Facilitated diffusion is not dependent on concentration gradients.
C. Na+/K+ ATPase is an example of secondary active transport.
D. Ligand-gated channels use ATP to move molecules against their concentration gradient.
E. Gap junction channels only occur between adjacent cells.
ANS: E (page 15); (A) doubling thickness halves diffusion rate (page 12), (B) facilitated
diffusion depends on concentration gradient, although transport proteins can become
saturated at high solute concentrations (page 12), (C) Na+/K+ ATPase is an example of
primary active transport (page 13), (D) ligand-gated channels provide facilitated diffusion
when activated by the appropriate ligand.
2. Which of the following statements concerning G proteins is true?
A. Gs, Golf, and Gi all increase cAMP.
B. Glucagon and ACTH activate Gi.
C. Gi amplifies the effects of Gs.
D. Gq acts through IP3 and DAG.
E. Gr increases cGMP.
4
