3.04 - Management of osteoarthritis Questions and Answers 100% Verified

How should you manage OA of the knee? - 1. First - WEIGHT LOSS 2. Exercise to strengthen 3. Brace Is arthroscopy an effective treatment for OA? - No. Moseley study was unable to demonstrate any effect greater than placebo. Is arthroscopy proven to be effective in treating OA? - No Is glucosamine sulfate an effective OA treatment? - No. It's no better than a sugar pill in terms of efficacy. Is viscosupplementation an effective treatment for OA? - No. Small effect for hyaluronic acid (same as paracetomol). What are some disease modifying agents being developed to target the following tissues.. a) bone remodelling and sclerosis b) cartilage breakdown c) synovial hypertrophy d) altered fat metabolism - a) bisphosphonates; calcitonin; BMP7 b) IL-1beta inhibition; MMP inhbition; Cathepsin K inhibition; Aggrecanase inhibitors; BMP7; FGF18 c) TNF inhibitors; IL-1 inhibitors; bradykinin antagonists d) leptinWhat are the 3 stages of treatment for OA? Which two are currently mostly ignored?? - Prevention - obesity - injury Progression - reduce load - modify disease Palliation - analgesia - jt replacement What are the aims of OA management? - 1. Patient education about both the disease and its management 2. Pain control 3. Improvement of function 4. *Alteration of the disease process and its consequences* (holy grail)