COMSAE ALL EXAMS BUNDLED TOGETHER[LATEST 2024\2025 QUESTIONS AND
VERIFIED ANSWERS
1. Clinical Medicine
Question: A 55-year-old male presents with chest pain and shortness of breath. He has a history
of hypertension and smoking. Physical examination reveals a systolic murmur best heard at the
left sternal border. What is the most likely diagnosis?
Answer: Aortic stenosis. The systolic murmur at the left sternal border is characteristic of aortic
stenosis, which is often seen in patients with a history of hypertension and smoking.
2. Pharmacology
Question: A patient is prescribed a new medication for hypertension and reports experiencing a
persistent dry cough. Which class of medication is most likely responsible for this side effect?
Answer: ACE inhibitors. A dry cough is a well-known side effect of ACE inhibitors due to the
accumulation of bradykinin.
3. Microbiology
Question: Which of the following pathogens is most commonly associated with hospital-
acquired pneumonia?
Answer: Pseudomonas aeruginosa. Pseudomonas aeruginosa is a common pathogen in hospital-
acquired pneumonia, particularly in patients with underlying chronic lung disease or those on
mechanical ventilation.
4. Physiology
Question: During exercise, which of the following changes occurs in the cardiovascular system
to meet increased oxygen demand?
Answer: Increased cardiac output. During exercise, the cardiovascular system responds by
increasing cardiac output, which is achieved through an increase in both heart rate and stroke
volume.
5. Pathology
Question: A patient presents with jaundice, ascites, and an elevated level of alkaline
phosphatase. A liver biopsy reveals ductal proliferation and fibrosis. What is the most likely
diagnosis?
VERIFIED ANSWERS
1. Clinical Medicine
Question: A 55-year-old male presents with chest pain and shortness of breath. He has a history
of hypertension and smoking. Physical examination reveals a systolic murmur best heard at the
left sternal border. What is the most likely diagnosis?
Answer: Aortic stenosis. The systolic murmur at the left sternal border is characteristic of aortic
stenosis, which is often seen in patients with a history of hypertension and smoking.
2. Pharmacology
Question: A patient is prescribed a new medication for hypertension and reports experiencing a
persistent dry cough. Which class of medication is most likely responsible for this side effect?
Answer: ACE inhibitors. A dry cough is a well-known side effect of ACE inhibitors due to the
accumulation of bradykinin.
3. Microbiology
Question: Which of the following pathogens is most commonly associated with hospital-
acquired pneumonia?
Answer: Pseudomonas aeruginosa. Pseudomonas aeruginosa is a common pathogen in hospital-
acquired pneumonia, particularly in patients with underlying chronic lung disease or those on
mechanical ventilation.
4. Physiology
Question: During exercise, which of the following changes occurs in the cardiovascular system
to meet increased oxygen demand?
Answer: Increased cardiac output. During exercise, the cardiovascular system responds by
increasing cardiac output, which is achieved through an increase in both heart rate and stroke
volume.
5. Pathology
Question: A patient presents with jaundice, ascites, and an elevated level of alkaline
phosphatase. A liver biopsy reveals ductal proliferation and fibrosis. What is the most likely
diagnosis?
