Lecture 11 Drexel Pathophysiology
What is agenesis? - ANS-1 or both kidneys fail to develop (can be fatal)
What is hypoplasia? - ANS-smaller size of kidney, underdevelopment
What happens in a horseshoe kidney? - ANS-kidneys fuse together in womb (doesnt affect
function at all)
What causes autosomal dominant polycystic kidney disease? - ANS-mutation on chrom. 16 or
crom. 4
Signs and symptoms of ADPKD - ANS--pain, hematuria(blood in urine), infections, hypertension
Who has ADPKD - ANS--present in 10% of persons with end stage renal disease
-may progress to chronic renal failure
-cerebral aneurysm can occur in 20% of cases
What is autosomal recessive adult polycystic kidney disease - ANS-serious manifestations are
present at birth, with rapid progression to renal failure
WHat is adult polycystic kidney disease? - ANS-is a genetic disorder in which abnormal cysts
develop and grow in the kidneys.
What is nephritic syndrome? - ANS--causes inflammatory damage to capillary wall
-hematuria, azotemia(waste product in blood), oliguria (small production of urine), and
hypertension
What is nephrotic syndrome? - ANS--causes increased glomerular permeability to proteins
-proteinuria( protein in urine), lipiduria (lipids in urine) and edema (swelling)
What is chronic glomerulonephritis? - ANS--kidney disorder caused by slow, cumulative damage
and scarring of the tiny blood filters in the kidneys. These filters, known as glomeruli, remove
waste products from the blood
-this disease can progress to end-stage renal disease over a period of years
Glomerular disease - ANS--glomerular disorders affect the glomerular capillary membrane
structures that filter materials from the blood
-nephritic syndromes are caused by diseases that produce proliferative inflammatory responses
that decrease the permeability of the glomerular capillary membrane
-the nephrotic syndrome is caused by disorders that increase the permeability of the glomerular
capillary membrane, causing massive loss of protein in the urine
What is agenesis? - ANS-1 or both kidneys fail to develop (can be fatal)
What is hypoplasia? - ANS-smaller size of kidney, underdevelopment
What happens in a horseshoe kidney? - ANS-kidneys fuse together in womb (doesnt affect
function at all)
What causes autosomal dominant polycystic kidney disease? - ANS-mutation on chrom. 16 or
crom. 4
Signs and symptoms of ADPKD - ANS--pain, hematuria(blood in urine), infections, hypertension
Who has ADPKD - ANS--present in 10% of persons with end stage renal disease
-may progress to chronic renal failure
-cerebral aneurysm can occur in 20% of cases
What is autosomal recessive adult polycystic kidney disease - ANS-serious manifestations are
present at birth, with rapid progression to renal failure
WHat is adult polycystic kidney disease? - ANS-is a genetic disorder in which abnormal cysts
develop and grow in the kidneys.
What is nephritic syndrome? - ANS--causes inflammatory damage to capillary wall
-hematuria, azotemia(waste product in blood), oliguria (small production of urine), and
hypertension
What is nephrotic syndrome? - ANS--causes increased glomerular permeability to proteins
-proteinuria( protein in urine), lipiduria (lipids in urine) and edema (swelling)
What is chronic glomerulonephritis? - ANS--kidney disorder caused by slow, cumulative damage
and scarring of the tiny blood filters in the kidneys. These filters, known as glomeruli, remove
waste products from the blood
-this disease can progress to end-stage renal disease over a period of years
Glomerular disease - ANS--glomerular disorders affect the glomerular capillary membrane
structures that filter materials from the blood
-nephritic syndromes are caused by diseases that produce proliferative inflammatory responses
that decrease the permeability of the glomerular capillary membrane
-the nephrotic syndrome is caused by disorders that increase the permeability of the glomerular
capillary membrane, causing massive loss of protein in the urine
