Pharm Calcium Channel Blockers & Beta Blockers Study Guide

What are the L-type Calcium Channel Blockers (CCB)? Non-DHP, oral DHP, IV DHP. Non-DHP: - Verapamil - Diltiazem oral DHP: - Nifedipine - Amlodipine IV DHP: - Nicardipine - CLevidipine CCB Pharmacokinetics (bioavailability, metabolism, half life) Bioavailability: - good oral absorption but reduced availability due to hepatic first pass effect - P-glycoprotein substrates Metabolism: - CYP3A4 Half-Life: - variable 1.3 - 64 hours Pharmacokinetics of Verapamil (bioavailability, metabolism, half life) Bioavailability: 20-35% Onset of Action: 1-2 hours (oral), 1-5 min (IV) Protein binding: 90% Metabolism: CYP3A4 Half-Life: 4.5-12 hours Pharmacokinetics of Diltiazem (bioavailability, metabolism, half life) Bioavailability: 40% Onset of Action: 30-60 min (oral), 3 min (IV) Protein binding: 75%