510 CCB Study Guide- Questions and Correct Answers

The primary cause of angina pectoris is an imbalance between --- --- of the heart and --- --- to the heartoxygen requirement; oxygen supply episodes of angina in unstable angina occur at --rest unstable angina is typically caused by -- -- around an atherosclerotic plaque causing a reduction in blood flowclot formation CCB act by blocking -- -- -- and thereby preventing vascular smooth muscle and cardiac cell contractiontransmembrane calcium channels Current CCB's on the market block -- type calcium channels which are found inL - cardiac, skeletal, and smooth muscle - neurons - endocrine cells - bone DHPs- amlodipine - felodipine - nicardipine - nifedipine Non-DHPs- Diltiazem - Verapamil Amlodipine - Oral Bioavailability - Indication - Half-life- 65-90% - Angina, HTN - 30-50 h felodipine - oral bioavailability - indication - Half-life- 15-20% - HTN, Raynaud's - 11-16 h nicardipine - oral bioavailability - indication - half-life- 35% - Angina, HTN