Pharmacology I - Calcium Channel Blockers Questions and Answers

Currently, all CCBs on the market target the __-type voltage activated calcium channel. A) T B) N C) R D) L E) P/QD) L *Currently, all CCBs on the market traget the L-type channel.* CCBs have greater effect on *arterial* or *venous smooth muscle.*CCBs have greater effect on *arterial smooth muscle.* "All CCBs relax arterial smooth muscle, but they have less effects on venous beds." True or false... CCBs have no significant effect on cardiac preload.True! "CCBs inhibit calcium channel function, which leads to smooth muscle relaxation and negative __________ and __________ effects in the heart."negative *inotropic* and *chronotropic.* Put these steps in the correct order in terms of vascular smooth muscle contraction... - Enhance binding of Ca to calmodulin - Extracellular Ca moves into cell - Intracellular Ca release - Myosin light-chain kinase activated - Channel opens in response to membrane depolarization - Phosphorylation of the myosin light chain leads to the contraction of smooth muscle.1) Channel opens in response to membrane depolarization 2) Extracellular Ca moves into cell 3) Intracellular Ca release 4) Enhance binding of Ca to calmodulin 5) Myosin light-chain kinase activated 6) Phosphorylation of the myosin light chain leads to the contraction of smooth muscle. Self note: change wording and maybe edit up this question a bit later. Not super happy with it. Which of these statements about CCBs is *false?* A) CCB absorption experiences significant first pass metabolism. B) CCBs generally have high protein binding C) The majority of CCBs are metabolized by CYP2C9 D) Elimination of CCBs varies widely from 1.3-64 hours. E) All of the above are trueC) The majority of CCBs are metabolized by CYP2C9