APHON Chemotherapy Overview correctly answered

APHON Chemotherapy OverviewPre-clinical Studies - correct answer purpose is to determine safe starting dose for humans Folic Acid - correct answer Positive effect on kids w/ lymphoblastic leukemia Clinical trials - correct answer comparing 2+ therapeutic tx in ctl setting to evaluate effect of intervention of specific disease/s Clinical Trial phase 1 - correct answer how much can you handle before breakdown? determine max tolerated dose of drug or drug combo. ID dose-limiting toxicities: highest dose for which incidence of dose limiting toxicities is <33% Clinical Trial Phase 1 Patient - correct answer advanced disease, good organ function, resistant to standard therapies Clinical Trial phase 2 - correct answer determines efficacy of new agent in tx of specific cancer types and validate toxicity & dosage data. info r/t drug administration, acute toxicity, & supporting care Clinical Trial phase 2 Patient - correct answer pt who show little to no response to prior tx usually selected w/ normal organ function, measurable tumor size, reasonable life expectancy & functional status. Includes pt who have not been treated w/ investigational drug Clinical Trial Phase 3 - correct answer determine value of agent r/t existing tx. Measure response, toxicity, survival & QOL Clinical trial Phase 3 Patient - correct answer large number of newly dx who receive tx and observed over long period of time