Extracellular Matrix & Cell Junctions Questions with 100 % correct answers | verified

The ECM is primarily composed of --? - Answer-specific ECM glycoproteins cells in tissues are physically connected to neighboring cells and/or ---? - Answer-the extracellular matrix what are some functions of the ECM? - Answer-tensile strength, incompressibility and elasticity what component of the ECM provide it's elasticity? - Answer-elastins what component of the ECM allows incompressibility? - Answer-hydrated GAG fibers (GlucosAminoGlycans) what component of the ECM provides tensile strength? - Answer-Collagen fibers --- is the most abundant protein in the human body - Answer-collagens what are the functions of collagen? - Answer-structural support, especially tensile strength to tissues collagen resists ---forces - Answer-tensile Where is type 1 collagen found? - Answer-bone, tendon, skin, etc. basal lamina is found in ----? - Answer-epithelial tissue in the assembly of collagen fibers, -- polypeptide subunits are wrapped to form ----. - Answer-3, coiled coil triple helix what is the characteristic repeat sequence consist of, when referring to the assembly of collagen fibers? - Answer-glycine-X-Ycollagen molecules assemble in fibrils by --- (---) causing striated appearance - Answer-overlapping (staggered) massively parallel structure of collagen in tendons yields--- - Answer-enormous strength in one direction ----is another glycoprotein component of ECM - Answer-fibronectin dimer Collagen fibril-fibronectin-integrin-actin forms a strong bridge between --- and --- - Answer-ECM and actin-cytoskeleton --- in addition to mediating cell contacts, also bind a wide range of ECM proteins, including --- (directly) - Answer-integrins, collagen ECM cytoskeleton contact regulated from both inside and outside of the cell. Is this true? - Answer-yes in addition to serving as "anchors" integrins --- - Answer-respond to signals