UAB BY 123L Exam 3 Questions and Answers 2024;full solution pack

karyotyping - number and type of chromosome present Barr body - -condensed inactive X chromosome near nucleus of cell -all females have 1 Barr body nondisjunction - failure of chromosomes to separate during meiosis autosomal nondisjunction - -failure of chromosomes (other than sex chromosomes) to separate during meiosis -exs: trisomy 21, trisomy 18 translocation - portion of one chromosome is transferred to another (usually nonhomologous) abnormal egg (XX) x normal sperm (X) - -zygote: XXX -expected sex: female -# of Barr bodies: 2 -triple-X syndrome abnormal egg (XX) x normal sperm (Y) - -zygote: XXY -expected sex: male -# of Barr bodies: 1 -Klinefelter's syndrome abnormal egg (0) x normal sperm (X) - -zygote: 0X -expected sex: female -# of Barr bodies: 0-Turner's syndrome abnormal egg (0) x normal sperm (Y) - -zygote: Y0 -expected sex: male -# of Barr bodies: 0 -nonviable; not seen normal egg (X) x abnormal sperm (YY) - -zygote: XYY -expected sex: male -# of Barr bodies: 0 -Jacob's syndrome isolation of DNA - 1. homogenization 2. deproteinization 3. precipitation homogenization - -solubilizing membranes and denaturing proteins -exposes DNA -mechanical disruption: blender -added salt: pulls water away -added detergent: breaks down cell wall